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ProteomicsA2M Q975C and C3 Q1013C disulfide mutants
Mutant A2M and C3 with disulfides replacing their thiol esters were disulfide mapped via pepsin digests.
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD019082 | Pride
Human c3 a2m 
ProteomicsN-glycosylation analysis of human complement component C3 LC-MS
The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the ons...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034083 | Pride
Lc-ms c3 
ProteomicsN-glycosylation analysis of human complement component C3 LC-MS - annotation data
The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the ons...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035126 | Pride
Complement c3 
Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
MetabolomicsMulti-omics insights into the effects of Citrus reticulata-derived Bacillus cereus C3X-5 on the fermentation quality of cigar tobacco leaves
This study investigates the potential of Bacillus cereus C3X-5, a strain isolated from Citri Reticulatae Pericarpium (CRP), as a bio-enhancer for improving cigar tobacco leaves (CTL) fermentation quality. By integrating physicochemical analysis, metagenomics, and untargeted metabolomics, we systemat...
2026-07-24 | MTBLS15119 | MetaboLights
MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
ProteomicsComplement C3 deposition on nucleic acids is characteristic of immune complex initiated classical pathway overdrive in lupus erythematosus
Systemic lupus erythematosus is progressive, immune complex-mediated autoimmune disease targeting numerous organs. A central feature of the disease is the development of antibodies against nuclear components, including DNA. Antibodies against double-stranded DNA are so characteristic of this disease...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-26768 | biostudies-arrayexpress
MetabolomicsMulti-omic profiles of human nonalcoholic fatty liver disease tissue highlight heterogenic phenotypes
Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms in, e.g. APOC3, ...
2015-12-07 | MTBLS174 | MetaboLights
ProteomicsGlycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation
This dataset comprises site-specific glycopeptide analysis of complement component C3 from plasma samples of 816 adults from the Korčula cohort (Croatia). C3 glycopeptides were enriched using Concanavalin A lectin affinity chromatography and analyzed by nano-LC-MS/MS. The study characterizes the N-g...
ORGANISM(S): Homo sapiens (Human) 
2026-05-30 | PXD074569 | Pride
Glycoproteomics Complement c3 High-mannose glycans N-glycosylation 
MetabolomicsSystematic analyses of lipid mobilization by human lipid transfer proteins

Lipid transfer proteins (LTPs) maintain the specialised lipid compositions of biological membranes, and many are associated with disease. In eukaryotes, they support organellar functions by transporting lipids between compartmentalised metabolic pathways. However, for the majority of the hundreds...

2025-11-14 | MTBLS9567 | MetaboLights
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