Sort   by:  
 Page size 
ProteomicsSampling from proteome to HLA-DR ligandome
Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-24 | MSV000082848 | MassIVE
ProteomicsPresentation of the Extra-Cellular Domain of the Sars2 Spike Glycoprotein by Immunopeptidomic Profiling of HLA-II Bound Peptides from Human Dendritic Cells
In the present study we sought to identify the naturally processed and presented immunopeptidome of the SARS-CoV-2 spike glycoprotein from human antigen presenting cells. Monocyte-derived dendritic cells from a panel of healthy human subjects representing a majority of the HLA-DRB1 allele usage with...
ORGANISM(S): Sars Coronavirus (ncbitaxon:227859) Bos (ncbitaxon:9903) Homo Sapiens (ncbitaxon:9606) 
2020-05-21 | MSV000085456 | MassIVE
ProteomicsAccurate prediction of antigen presentation for HLA class II across loci using tailored data acquisition and refined machine learning
Accurate prediction of antigen presentation by Human Leukocyte Antigen (HLA) class II molecules is crucial for rational development of immunotherapies and vaccines targeting CD4 T cell activation. So far, most prediction methods for HLA class II antigen presentation have focused on HLA-DR due to lim...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD044810 | Pride
Hla-class ii Netmhciipan-4.3 Antigen presentation Machine learning Hla-dp 
ProteomicsDeep motif deconvolution of HLA-II peptidomes
CD4 T cells are key for priming and regulating immune recognition of infected and cancer cells, but predictions of class II epitopes have limited accuracy. We profiled over 100’000 HLA-II ligands by Mass Spectrometry and developed a novel motif deconvolution algorithm to analyze these data. Our work...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-18 | MSV000096130 | MassIVE
ProteomicsDefining HLA-II ligand processing and binding rules with mass spectrometry enhances cancer epitope prediction
Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and control tumor growth. However, it remains difficult to predict the antigens that will be presented by human leukocyte antigen class II molecules (HLA-II) - hindering efforts to optimally target them therapeutically...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-18 | MSV000083991 | MassIVE
TranscriptomicsTranscription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells
Effect of absence of interaction with MHC class II on memory CD4 T cells
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-890 | biostudies-arrayexpress
MetabolomicsNMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort
Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nu...
2018-10-02 | MTBLS395 | MetaboLights
UnknownVisualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.
Not available
S-EPMC379191 | biostudies-literature
ProteomicsTuning DO:DM ratios modulates HLA class II immunopeptidomes
Major Histocompatibility Complex Class II antigen presentation underlies a wide range of immune responses in health and disease. Although peptide ligand binding affinity has been the major focus for explaining and predicting class II antigens, we know that the levels and activities of accessory mol...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD024392 | Pride
Hla-ii Mhc Dm Antigen presentation Do Orbitrap 
ProteomicsHigh-throughput MS-based immunopeptidomics
Comprehensive knowledge of the HLA class-I and class-II peptides presented to T-cells is crucial for designing innovative therapeutics against cancer and other diseases. However methodologies for their extraction for mass-spectrometry analysis have been a major limitation. We designed a novel high-t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-19 | MSV000082184 | MassIVE
Sort   by:  
 Page size