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TranscriptomicsAlternative Isoform Regulation in Human Tissue Transcriptomes
Through alternative processing of pre-mRNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based on deep sequencing of...
ORGANISM(S): Homo sapiens 
2008-09-30 | E-GEOD-12946 | biostudies-arrayexpress
TranscriptomicsSingle-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms
Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we established an expe...
ORGANISM(S): Homo sapiens 
2021-06-16 | E-MTAB-7334 | biostudies-arrayexpress
TranscriptomicsTunable protein synthesis by transcript isoforms in human cells (Transcript Isoforms in Polysomes sequencing: TrIP-seq)
Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profil...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69352 | biostudies-arrayexpress
ProteomicsEvolution from an intronic Alu insertion generates a human-specific TAF8 isoform contributing to TFIID assembly complexity in the human lineage
Despite its centrality in the regulation of RNA polymerase II transcription in all eukaryotes, the general transcription factor TFIID exhibits several layers of variability in different tissues and developmental stages, representing an underexplored hub of evolutionary innovations. Here we describe ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-28 | PXD072860 | Pride
Ribosomes Isoaspartate Rna modificationspas  intronic polyadenylation  alu  primate  human-specific isoform 
GenomicsAMPKβ1/β2 isoform-specific gene expression profile in human induced pluripotent stem cells
AMPKβ1/β2 isoform-specific gene expression profile in human induced pluripotent stem cells
PRJNA602614 | ENA
ProteomicsThe Human 2-Cys Peroxiredoxins Form Widespread, Cysteine-Dependent- And Isoform-Specific Protein-Protein Interactions.
Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-translational modification triggered by H2O2 acting as a second messenger. However, H2O2 reacts poorly with most cysteine thiols and it is not clear how it discriminates between cysteines to trigger appropriate sign...
ORGANISM(S): Homo sapiens (Human) 
2021-05-04 | PXD024114 | Pride
Protein thiol oxidation Cysteine sulfenic acid Hydrogen peroxide Thiol disulfide exchange Peroxiredoxin  redox signaling  redox relay 
UnknownGalectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
Not available
S-EPMC10895193 | biostudies-literature
ProteomicsDynamics and consequences of widespread transcript isoform changes during neuronal differentiation
Static gene expression programs have been extensively characterized in stem cells and mature human cells. However, the dynamics of RNA isoform change upon cell-state transitions during cell differentiation, and the determinants and functional consequences have largely remained unclear. Here, we used...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD046084 | Pride
Cell differentiation Neurogenesis Multi-omics Rna isoform Nanopore sequencing 
TranscriptomicsRNA-seq of human primary ovarian granulosa cells with knockdown of ESR2 isoform 1, treated with estradiol
ERβ1 is the predominant isoform mediating transcriptional activity in granulosa cells; however, ERβ1-specific target genes remain largely unknown. Here, we performed transcriptomic analysis of primary human granulosa cells with specific knockdown of ERβ1 and stimulation with estradiol (E2), an ERβ a...
ORGANISM(S): Homo sapiens 
2026-06-30 | E-MTAB-16651 | biostudies-arrayexpress
TranscriptomicsAllele-Specific Expression in Human Brain and Liver
Systematic survey of gene and isoform allele-specific expression in human brain and liver tissues, and description of optimised bioinformatic and statistical methods to accurately measure allele-specific expression. DNA-seq data for the same set of samples have been deposited at the European Nucleot...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-2259 | biostudies-arrayexpress
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