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GenomicsAntitumor effects of the hydralazine-valproate combination in lymphoma
Antitumor effects of the hydralazine-valproate combination in lymphoma
PRJNA713994 | ENA
ProteomicsHydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
Many safe and effective drugs have unknown targets, limiting opportunities to extend their use to other disease states with overlapping etiologies. Here, we have elucidated the mechanism of action of the direct vasodilator, hydralazine (HYZ), which has been used for more than seven decades and remai...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-10-24 | PXD067316 | Pride
Glioblastoma Hydralazine Lc-ms Preeclampsia Mechanisms of action 
TranscriptomicsEpigenetic therapy with hydralazine and magnesium valproate added to chemoradiation in cervical carcinoma.
As a number of epigenetic alterations have been described in cervical cancer which may participate in the development and progression of this tumor, and the primary treatment for locally advanced disease is concurrent chemoradiation, we wanted to evaluate the efficacy and safety of hydralazine and v...
ORGANISM(S): Homo sapiens 
2007-07-31 | GSE8604 | GEO
TranscriptomicsAntitumor effects of the hydralazine-valproate combination in lymphoma
Epigenetic alterations are common in both B cell and T cell lymphomas. These contribute to lymphomagenesis and treatment resistance, hence epigenetic therapy is being investigated. We evaluated the effects of the DNA-methyltrasferase inhibitor hydralazine and the histone deacetylase inhibitor valpro...
ORGANISM(S): Homo sapiens 
2021-03-13 | GSE168790 | GEO
UnknownHydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma.
Not available
S-EPMC8324788 | biostudies-literature
UnknownClinical Pharmacogenetics Implementation Consortium Guideline for NAT2 Genotype and Hydralazine Therapy.
Not available
S-EPMC12641075 | biostudies-literature
UnknownEffect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy.
Not available
S-EPMC6813860 | biostudies-literature
UnknownHydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission.
Not available
S-EPMC8752357 | biostudies-literature
UnknownHydralazine modifies Aβ fibril formation and prevents modification by lipids in vitro.
Not available
S-EPMC3033120 | biostudies-literature
UnknownHydralazine and Enzalutamide: Synergistic Partners against Prostate Cancer.
Not available
S-EPMC8391120 | biostudies-literature
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