hyperexcitability

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3-(4-hydroxyphenyl)acrylic acid (1)
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6-({4,5-dihydroxy-2-[hydroxy({2,3,4-trihydroxy-6-oxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1-yl})methyl]oxan-3-yl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid (1)
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Classification

viruses (1)

Study type

Transcription profiling by array (7)
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Lab affiliation

Baylor College of Medicine, Houston, TX, 77054 (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Korea (1)
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA (1)
Department of Pharmacology, University of Arizona College of Medicine - Tucson (1)
Fondazione Pisana per la Scienza (1)
Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany (1)
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium (1)
Motor Neuron Disease Research Centre, Macquarie University, NSW, 2113, Australia (1)
UK Dementia Research Institute at UCL, Cruciform Building, Gower Street, London, WC1E 6BT, UK. a.isaacs@ucl.ac.uk. (1)
University of Colorado Anschutz Medical Campus (1)
University of Nebraska, Lincoln (1)

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Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis

PRJNA1173233 | ENA

Cortical region confers neuron-type-specific vulnerability to human APP expression

Alzheimer’s Disease is a devastating and an irreversible neurodegenerative disease currently afflicting 50 million individuals worldwide, a number expected to escalate three-fold over the next 25 years. Preventative treatment is of dire importance, and yet, cellular mechanisms underlying early regio...

ORGANISM(S): Mus musculus (Mouse)

2024-06-28 | PXD053491 | Pride

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis

The full impact of apolipoprotein E4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on neuronal and network function remains unclear. We found hippocampal region-specific network hyperexcitability in young APOE4 knock-in (E4-KI) mice which predicted cognitive deficits at ol...

ORGANISM(S): Mus musculus

2025-12-18 | GSE279550 | GEO

Demyelination-Induced Glutamatergic Imbalance Mediates Hippocampal Hyperexcitability

PRJNA1333491 | ENA

APP Causes Hyperexcitability in Fragile X Mice.

Not available

S-EPMC5156834 | biostudies-literature

Microcircuit failure in STXBP1 encephalopathy leads to hyperexcitability.

Not available

S-EPMC10772346 | biostudies-literature

Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients

PRJNA669045 | ENA