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MetabolomicsIsoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis
High-altitude hypoxia induces myocardial metabolic disorders, structural remodeling, and functional impairment, which threaten the health of highland populations. The interventional effects and molecular mechanisms of isoquercitrin (IQ), a natural flavonoid with cardiovascular protective activity, a...
2026-07-29 | MTBLS15192 | MetaboLights
ProteomicsAlterations of human plasma proteome profile on adaptation to high-altitude hypobaric hypoxia
For individuals migrating to or residing permanently at high-altitude regions, environmental hypobaric hypoxia is a primary challenge which induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such...
ORGANISM(S): Homo sapiens (Human) 
2019-03-27 | PXD012221 | Pride
Proteomics  high altitude  hypobaric hypoxia  complement and coagulation cascades  antioxidant  glycolysis. 
TranscriptomicsHippocampal response to Hypobaric Hypoxia
Sprague Dawley rats were exposed to Hypobaric Hypoxia for 1, 3 and 7 days followed isolation of Hippocampus. Microarray was performed utilizing RNA isolated from these samples. Each group included 5 animals. Agilent Rat Gene Expression 8X60K (AMADID: 028279) , Labeling kit: Agilent Quick-Amp labelin...
ORGANISM(S): Rattus norvegicus 
2016-03-01 | E-GEOD-66287 | biostudies-arrayexpress
ProteomicsProteomics analysis of the myocardium form chronic hypobaric hypoxia-induced mice model
C57BL/6J mice were assigned to the hypobaric hypoxia chamber for simulation of high-altitude conditions. iTRAQ proteomics analysis/nanoUHPLC-MS/MS analysis was performed accordingly in the right myocardium of mice that had been allowed to develop hypoxia-induced pulmonary hypertension after hypobari...
ORGANISM(S): Mus Sp. 
2023-02-23 | PXD040342 |
TranscriptomicsLocust flight muscle: hypoxia-treated vs control
Background: Hypoxia can affect aerobic organisms profoundly. Biological responses to extreme hypoxia have been well studied. However, it is not well characterized how living organisms respond to mild hypoxia, and how they distinguish different levels of hypoxia. Results: We examined the transcriptio...
ORGANISM(S): Locusta migratoria 
2012-12-12 | E-GEOD-33898 | biostudies-arrayexpress
TranscriptomicsEffects of chronic hypoxia on Duchenne Muscular Dystrophy Drosophila melanogaster model
In order to understand the chronic hypoxia (CH) effect upon the absence of dystrophin, Drosophila melanogaster wild type and the model for DMD (dmDys), in which all dystrophins expression was knocked out by iRNA, were exposed to high altitude hypoxia (hypobaric hypoxia) during a 16-day climbing per...
ORGANISM(S): Drosophila melanogaster 
2010-07-31 | E-GEOD-15879 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in whole blood of mice subjected to hypobaric hypoxia at Mt. Everest in vivo.
To determine hypoxia mediated changes in whole blood, normal swiss webster mice were gradually exposed to a chronic hypobaric hypoxic environment up to 8500m, for 2 weeks in vivo. Control, age-matched mice were maintained under normoxic conditions in Kathmandu (c. 1300 mts above sea level). Purpose:...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-15901 | biostudies-arrayexpress
ProteomicsThe plasma DIA proteomic analysis for humans aimming at exploring the mechanism of RIPC’s protective effect under hypobaric hypoxia condition.
The plasma proteome profiling data come from the humans who received remote ischemic preconditioning treatment and experienced hypobaric hypoxia exposure then.
ORGANISM(S): Homo Sapiens 
2022-01-25 | PXD031247 |
ProteomicsNitrated protein profile of rat hypoxic brain
In this work we have described the protein nitration profile in the brain of rats submitted to an experimental model of hypobaric hypoxia
ORGANISM(S): Rattus norvegicus (Rat) 
2014-07-30 | PXD001049 | Pride
Brain Rat Nitration Hypoxia 
GenomicsChronic hypobaric hypoxia induces exposure-duration-dependent transcriptomic remodeling in the mouse cochlea
Chronic hypobaric hypoxia induces exposure-duration-dependent transcriptomic remodeling in the mouse cochlea
PRJNA1512482 | ENA
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