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ProteomicsVitreous proteome of transgenic INSC94Y pigs compared to wild type
INSC94Y transgenic pigs serve as a valuable model for permanent neonatal diabetes mellitus. Through genetically engineered modifications in the insulin (INS) gene, this model presents with impaired insulin secretion, resulting elevated fasting blood-glucose levels (hyperglycemia) [1].One of the seve...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-08-27 | PXD038198 | Pride
Quantitative label-free lc-ms/ms  diabetes mellitus  permanent neonatal diabetes  diabetic retinopathy  genetically modified pig  insc94y  porcine model  vitreous 
UnknownChronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs.
Not available
S-EPMC7862560 | biostudies-literature
ProteomicsThe porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-04 | PXD017274 | Pride
Differential proteomics Innate immune cell Neutrophil granulocyte Diabetes 
UnknownFrom kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD.
Not available
S-EPMC12804299 | biostudies-literature
UnknownThe Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Not available
S-EPMC5518720 | biostudies-literature
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