Sort   by:  
 Page size 
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080850 | MassIVE
TranscriptomicsMechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γc, We find that in the IL-15/IL-15Rα/IL-2Rβ/γc quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γc identically to the IL-2/IL-2Rα/IL...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-40350 | biostudies-arrayexpress
GenomicsRunx3 Regulates Interleukin-15-Dependent Natural Killer Cell Activation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-52625 | biostudies-arrayexpress
TranscriptomicsINTERLEUKIN 15-DEPENDENT T CELL-LIKE INNATE INTRAEPITHELIAL LYMPHOCYTES DEVELOP IN THE INTESTINE AND TRANSFORM INTO LYMPHOMAS IN CELIAC DISEASE
The nature of gut intraepithelial lymphocytes lacking antigen receptors remains controversial. Herein we showed that, in humans and in mice, innate intestinal intraepithelial lymphocytes expressing intracellular CD3 (iCD3+ innate IELs) differentiate along an Id2 transcription factor (TF)-independent...
ORGANISM(S): Homo sapiens 
2016-11-23 | E-MTAB-4960 | biostudies-arrayexpress
ModelsCoulibaly2019 - Interleukin-15 Signaling in HIF-1a Regulation in Natural Killer Cells
This is a mathematical model comprised of non-linear ordinary differential equations describing the dynamic relationship between hypoxia-inducible factor-1 alpha (HIF-1a) mRNA, HIF-1a protein, and interleukin-15-mediated upstream signalling events in natural killer cells from human blood. Regulatory...
2024-09-02 | BIOMD0000000867 | BioModels
TranscriptomicsRunx3 function in splenic NK cells activated in vivo by IL-15.
NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 regulated genes, NK cells were isolated from spleen of IL15/Ra injected WT...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-50120 | biostudies-arrayexpress
GenomicsGenome-wide maps of Runx3 bound regions in splenic NK cells activated in vivo with IL-15
ChIP-seq was conducted using freshly isolated splenic WT NK cells from IL-15/Ra treated mice with anti-Runx3 antibody (Ab) and non-immune serum (NIS) as control. Runx3 and NIS IP from splenic NK cells of IL-15/Ra treated WT mice, isolated by negative selection using NK cell isolation kit (R&D) follo...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-50126 | biostudies-arrayexpress
ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080767 | MassIVE
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo sapiens (Human) 
2016-08-08 | PXD002386 | Pride
Phosphorylation Il-2 Receptor complex assembly Il-15 Interactome 
TranscriptomicsMechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15
Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γc, We find that in the IL-15/IL-15Rα/IL-2Rβ/γc quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γc identically to the IL-2/IL-2Rα/IL...
ORGANISM(S): Mus musculus 
2012-11-01 | GSE40350 | GEO
Sort   by:  
 Page size