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To delineate mechanisms for psoriasis pathogenesis driven by the interleukin-17A, proteomic dysregulations were studied in a Human Primary Keratinocyte model system. Label-free quantification was performed and fold-changes were obtained for abundances of proteins in IL-17A treated keratinocytes vers...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-11 | MSV000090116 | MassIVE
Viral mimicry of Interleukin-17A by SARS-COV-2 ORF8
Dissociating fibrosis from inflammation in systemic sclerosis – the case of interleukin-17A
IL-17A is a pro-inflammatory cytokine that promotes host defense against infections and contributes to the pathogenesis of chronic inflammatory diseases. Dendritic cells (DC) are antigen-presenting cells responsible for adaptive immune responses. Here, we report that IL-17A induces intense remodelin...
ORGANISM(S): Homo sapiens 
Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro
Objectives. Interleukin-17A (IL-17A) levels are increased in SSc skin and other organs but its role in fibrosis development is highly debated. Since epithelial cells are preferential targets of IL-17A, we aimed at investigating the role of IL-17A in the interactions between epidermis and dermis. Met...
ORGANISM(S): Homo sapiens 
2020-02-11 | GSE122305 | GEO
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