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ProteomicsThe human iRHOM2 interactome upon KRAS expression
ADAM17 is a cell surface protease that controls the release of the ectodomains of signalling proteins including EGFR ligands and the primary inflammatory cytokine TNF. Reflecting this important role in signalling, dysregulated ADAM17 activity is linked to many human diseases including immunodeficien...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD063983 | Pride
Protease Signalling Rhomboid 
ProteomicsPhosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE
TACE (TNFa Converting Enzyme), is responsible for cleavage (‘shedding’) of membrane-tethered signaling molecules such as TNF of EGFR ligands. TACE interacts with iRhom2, which mediates the exit of TACE from the endoplasmic reticulum. In this study we analyze a new role for iRHOM2, where a fraction o...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD007763 | Pride
Irhom2 tace phosphorylation 
GenomicsiRHOM2 deficiency causes environmentally directed immunodysregulatory disease
iRHOM2 deficiency causes environmentally directed immunodysregulatory disease
PRJNA741290 | ENA
GenomicsiRHOM2 deficiency causes environmentally directed immunodysregulatory disease
iRHOM2 deficiency causes environmentally directed immunodysregulatory disease
PRJNA741289 | ENA
ProteomicsProteomics of ADAM17 and iRhom2 KO microglia using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054898 | Pride
Mouse Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
ProteomicsSecretomics of ADAM17 and iRhom2 KO BV2 cells using high-performance secretome protein enrichment with click sugars
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is unknown. Another microglia-expressed AD ri...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-10 | PXD054894 | Pride
Mouse Bv2 Hispecs Timstof pro Adam17 Diapasef Microglia Irhom2 Secretome Rhbdf2 
GenomicsRole of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-dependent Adaptation
Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-dependent Adaptation
PRJNA1114810 | ENA
TranscriptomicsRole of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-dependent Adaptation
The cell surface metalloprotease ADAM17 and its binding partners iRhom2 and iRhom1 modulate cell-cell interactions by mediating the release of membrane proteins such as TNFa and EGFR-ligands from the cell surface. Most cell types express both iRhoms, though myeloid cells exclusively express iRhom2, ...
ORGANISM(S): Mus musculus 
2024-05-28 | GSE268171 | GEO
ProteomicsA highly conserved luminal ER exit motif in the pseudoproteases iRhom1 and iRhom2 is indispensable for TNF������ and EGF receptor ligand release
Membrane-tethered signalling proteins such as TNF������ and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the ER exit and activity of ADAM17. Yet, their structural requirements to promote ER exit re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-05-25 | PXD016948 | Pride
Tnf������ Receptors Cell biology Egf 
GenomicsiRhom2 Promotes Lupus Nephritis through ADAM17-Dependent TNF-α and EGFR Signaling
iRhom2 Promotes Lupus Nephritis through ADAM17-Dependent TNF-α and EGFR Signaling
PRJNA421160 | ENA
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