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TranscriptomicsGene expression profiling indicates inflammatory pathways involved in IUGR due to placental insufficiency
Intrauterine growth restriction (IUGR) represents a major obstetric challenge with perinatal complications and a risk factor of developing disease in adult life. Placental insufficiency is one of the common features accompanying IUGR. The aim of this study was to evaluate global placental gene ...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-GEOD-12216 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in normal and IUGR pancreatic islets
Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress
TranscriptomicsRegulation of Fetal Liver Growth in a Model of Diet Restriction in the Pregnant Rat
The present study was designed to test the hypothesis that limited growth of the fetal liver in the model of maternal fasting is independent of well-characterized signaling mechanisms that are known to regulate somatic growth in adult animals. We profiled the fetal hepatic transcriptome and translat...
ORGANISM(S): Rattus norvegicus 
2016-07-18 | E-GEOD-77112 | biostudies-arrayexpress
TranscriptomicsIntrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in th...
ORGANISM(S): Oryctolagus cuniculus 
2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress
Genomicsgut microbiota of IUGR pig
gut microbiota of IUGR pig Metagenome
PRJNA1067849 | ENA
TranscriptomicsEffect of IUGR on postnatal day 14 pancreatic islets
IUGR is a common complication of pregnancy. We have created a rat model of IUGR which mimics placental insufficiency. Surgery is performed at embryonic day 18 and dams are allowed to deleiver spontaneously. At postnatal day 14, we isolate pancreatic islets and have compared their gene expression wit...
ORGANISM(S): Rattus norvegicus 
2013-07-13 | E-GEOD-48822 | biostudies-arrayexpress
TranscriptomicsHuman IUGR placentas
IUGR (Intra-Uterine Growth Restriction) refers to a condition where the foetus does not reach its growth potential in utero. It is supposed to be often linked with placental dysfunction, especially of vascular origin. In this study, 4 pools of three placentas from human normal pregnancies and 4 pool...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-MTAB-1956 | biostudies-arrayexpress
GenomicsIUGR and Placental Microbiome
16S rRNA gene sequencing information of placental Microbiome of 20 IUGR and 20 normal samples.
PRJEB25504 | ENA
TranscriptomicsTranscription profiling of rat heart, kidney and placenta from fetuses obtained from dams with diet-induced intra-uterine growth restriction vs. normal
Pregnant rats were randomly divided into two groups. Dams were then housed individually and fed throughout gestation a 22 % protein diet, representing the control group (C, n=5), or an 9% isocaloric protein diet, representing the low-protein (LP, n=6). Both diets were isocaloric, because the protei...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-MEXP-1015 | biostudies-arrayexpress
TranscriptomicsExpression analysis of genes in Rattus norvegicus lungs at postnatal day 4, 10 and 21 after intrauterine growth restriction induced by low protein diet
We performed RNA microarray in a low protein diet (LPD) model of IUGR at three key time points of alveolarization process. IUGR and control rat pups had been studied for each time point considered: on postnatal day 4 (P4) before beginning of the alveolarization process, on P10, peak of alveolarizat...
ORGANISM(S): Rattus norvegicus 
2014-10-29 | E-GEOD-56956 | biostudies-arrayexpress
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