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ProteomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome maintenance
Linkage-specific ubiquitin (Ub) chains dictate the functional outcome of many critical Ub-dependent signaling processes. However, the functions and targets of several poly-Ub topologies remain poorly understood due to a lack of tools for their specific detection and manipulation. To remedy this know...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD056493 | Pride
Ubiquitin  ubiquitin-proteasome system  k29-linked ubiquitylation  chromatin  epigenome 
ProteomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome maintenance
We applied a cell-based Ub replacement strategy enabling specific, conditional abrogation of each of the seven lysine-based Ub chain types in human cells to comprehensively profile global ubiquitylation changes resulting from disabling formation of individual Ub chain types. Focusing on K29-linked u...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD056295 | Pride
Human Ubiquitylation Ptm 
GenomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome integrity
Profiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome integrity
PRJNA1171407 | ENA
GenomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome integrity
Linkage-specific ubiquitin (Ub) chains dictate the functional outcome of many critical Ub-dependent signaling processes. However, the functions and targets of several poly-Ub topologies remain poorly understood due to a lack of tools for their specific detection and manipulation. To remedy this know...
ORGANISM(S): Homo sapiens 
2025-09-17 | GSE279218 | GEO
UnknownFunctional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity.
Not available
S-EPMC12669653 | biostudies-literature
ProteomicsFunctional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity
Linkage-specific ubiquitin chains govern the outcome of numerous critical ubiquitin-dependent signaling processes. However, the targets and functional impacts of linkage-specific ubiquitin modifications remain incompletely understood, due to a paucity of tools for their specific detection and manipu...
ORGANISM(S): Homo sapiens (Human) 
2025-10-21 | PXD056564 | Pride
K29 Epigenome maintenance Trip12 Ubiquitylation 
UnknownFunctional landscape of ubiquitin linkages connects K29-linked ubiquitylation to epigenome integrity
Not available
S-SCDT-10_1038-S44318-025-00599-7 | biostudies-other
UnknownCentral catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation.
Not available
S-EPMC5628404 | biostudies-literature
UnknownK29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Not available
S-EPMC4386640 | biostudies-literature
TranscriptomicsA combinatorial ubiquitin code degrades substrates protected by deubiquitylation
Reversibility of protein ubiquitylation play essential roles in cellular protein homeostasis. How substrates stabilized by deubiquitylation are directed for degradation remains largely elusive. Here, we show that the branched ubiquitin chains promote the degradation of the deubiquitylase (DUB) OTUD5...
ORGANISM(S): Homo sapiens 
2025-02-19 | GSE273273 | GEO
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