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ProteomicsThe multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported, the functional oligomeric state of the full-length...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD028039 | Pride
Glucocorticoid receptor Mass spectrometry Ligand-binding domain Sectors X-ray crystallography Fluorescence microscopy Mutations Quaternary structure Glucocorticoids Homodimerization 
ProteomicsDiptoindonesin G is a middle domain HSP90 modulator for cancer treatment
HSP90 inhibitors can target many oncoproteins simultaneously, but none have made it through clinical trials due to dose-limiting toxicity and induction of heat shock response, leading to clinical resistance. We identified diptoindonesin G (dip G) as an HSP90 modulator that can promote degradation of...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD035398 | Pride
Esr1  hsp90  heat shock  lbd mutations  diptoindonesin g  hsp90 inhibitor  y537s  hsp90 middle domain  er alpha 
UnknownGenetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci.
Not available
S-EPMC10879525 | biostudies-literature
ProteomicsAltered ceramide metabolism is a feature in the extracellular vesicle mediated spread of alpha-synuclein in sporadic and GBA-linked Lewy body disease
Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD) – collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutation contributes to the susc...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026980 | Pride
Exosomes Alpha-synuclein Ceramide Inflammation Lewy body disease Extracellular vesicles Glucocerebrosidase 
UnknownContribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson's disease.
Not available
S-EPMC7881566 | biostudies-literature
UnknownGBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.
Not available
S-EPMC3484986 | biostudies-literature
TranscriptomicsEffects of small molecules targeting the androgen receptor DNA-binding domain on prostate cancer cell transcriptome
Prostate cancer is a leading cause of cancer related death among men. Current Androgen Receptor (AR) antagonists often target the ligand binding domain (LBD). However, occurrence of resistance to drugs targeting the LBD is common due to emergence of mutations in the LBD or constitutively active vari...
ORGANISM(S): Homo sapiens 
2019-07-20 | GSE127816 | GEO
UnknownGlucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease.
Not available
S-EPMC3494984 | biostudies-literature
UnknownDifferential Effects of Cancer-Associated Mutations Enriched in Helix H3 of PPARγ.
Not available
S-EPMC7761077 | biostudies-literature
UnknownActivating ESR1 mutations in hormone-resistant metastatic breast cancer.
Not available
S-EPMC4009946 | biostudies-literature
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