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ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice (2)
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD018783 | Pride
Mouse i-ab mhcii peptidome  lc/ms/ms dda on qe mass spectrometer 
MetabolomicsMetabolic consequences of cobalamin scarcity in diatoms as revealed through metabolomics (Thalassiosira pseudonana study)

Diatoms perform about 20% of photosynthesis on earth, play a crucial role in forming the base of the marine food web, and sequester anthropogenic carbon into the deep ocean through the biological pump. In some areas of the ocean, diatom growth is limited by the organic micronutrient cobalamin (vi...

2019-06-04 | MTBLS703 | MetaboLights
MetabolomicsMetabolic consequences of cobalamin scarcity in diatoms as revealed through metabolomics (Navicula pelliculosa study)

Diatoms perform about 20% of photosynthesis on earth, play a crucial role in forming the base of the marine food web, and sequester anthropogenic carbon into the deep ocean through the biological pump. In some areas of the ocean, diatom growth is limited by the organic micronutrient cobalamin (vi...

2019-06-04 | MTBLS708 | MetaboLights
ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after only 1h exposure and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry (LC-MS...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD005840 | Pride
Co-exposure Hepatocytes Human Deoxynivalenol Zearalenone Lc-ms/ms 
ProteomicsHaemonchus contortus Global Somatic Proteome
Parasitic nematodes cause diseases that adversely impact on animal health and production. Although advances in genomics and transcriptomics are revolutionising the way we explore these parasites, there is a dearth of proteomic data to underpin or support fundamental discoveries. Here, using a high t...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2019-03-01 | PXD009956 | Pride
Haemonchus contortus Parasitic nematode Lc-ms/ms 
ProteomicsProteome dynamics during transition from exponential to stationary phase in yeast
Glycolysis is the central pathway for sugar metabolism in most living organisms. The single celled eukaryote yeast is a widely used model organism for higher eukaryotes in which the regulation of glycolysis is widely studied. S. cerevisiae is one of the few eukaryotic organisms that can efficiently ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-04-15 | PXD031412 | Pride
Growth Yeast Tmt quantification Orbitrap qe plus Glycolysis 
ProteomicsProtein mass spectrometry raw data of M7A, M7GA, M7A-DC, and M7GA-DC for DAR calculation in study of MSLN-directed DARPin-drug conjugates
Mesothelin (MSLN) is an attractive therapeutic target for precision cancer treatments. Here, we identify a MSLN-targeting DARPin, M7, which specifically binds to the protease-sensitive C-terminal region of MSLN. Furthermore, we develop two auristatin-based DARPin-drug conjugates (DARPin-DCs), M7A-DC...
ORGANISM(S): Escherichia coli 
2025-09-05 | PXD065630 | Pride
Lc/ms Protein-drug conjugates 
ProteomicsGigartina pilot scale protein extract BUP
Seaweeds are attracting substantial interest as novel sources of sustainable food protein, as they are established sources of industrial hydrocolloids and have reasonable protein content. In this study we investigate the protein composition and quality of a seaweed protein extract (SPE) from Gigarti...
ORGANISM(S): Solanum tuberosum (Potato) 
2022-09-26 | PXD034435 | Pride
Gigartina Rhodophyta Alternative food protein Seaweed 
ProteomicsData-independent immunopeptidomics discovery of low-abundant bacterial epitopes
Mass spectrometry-based immunopeptidomics is a powerful approach to uncover peptides presented by human leukocyte antigen (HLA) molecules and serves as an important discovery tool guiding vaccine design and immunotherapies. While data-dependent acquisition (DDA) has been the standard for navigating ...
ORGANISM(S): Listeria monocytogenes Homo sapiens (Human) 
2025-08-21 | PXD063560 | Pride
Listeria Spectrum-centric Dia Immunopeptidomics Peptide-centric 
ProteomicsA male-specific steroid hormone controls female reproductive biology in the malaria mosquito
Insects, unlike vertebrates, are generally believed to lack steroid hormones with functions predominantly associated with adult male biology. In the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to both control egg development in females and induce mating refra...
ORGANISM(S): Anopheles gambiae str. PEST 
2022-04-21 | PXD032157 | Pride
Lc-ms/ms Malaria Ejaculome Mosquito Qe-hf 
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