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MetabolomicsExplaining combinatorial effects of mycotoxins Deoxynivalenol and Zearalenone in mice with urinary metabolomic profiling
Urine metabolic profiling of mice was conducted utilizing gas chromatography-mass spectrometry (GC-MS) to investigate the combinatory effect of mycotoxins deoxynivalenol (DON) and zearalenone (ZEN) on the metabolism of the mice. Experiments were conducted by means of five-week-old mice which were in...
2021-02-11 | MTBLS580 | MetaboLights
MetabolomicsGC-MS based targeted metabolic profiling identifies changes in the wheat metabolome following deoxynivalenol treatment
Fusarium graminearum and related species commonly infest grains causing the devastating plant disease Fusarium head blight (FHB) and the formation of trichothecene mycotoxins. The most relevant toxin is deoxynivalenol (DON), which acts as a virulence factor of the pathogen. FHB is difficult to contr...
2014-10-17 | MTBLS112 | MetaboLights
TranscriptomicsBarley host response to the direct application of the trichothecene mycotoxin deoxynivalenol
Barley florets (cv. Morex) were treated with 2.0 microgram deoxynivalenol per floret via a 10 microliter solution or mock inoculated with water. Samples were collected at 1, 12, 24, and 48 hours after inoculation. ****[PLEXdb(http://www.plexdb.org) has submitted this series at GEO on behalf of the...
ORGANISM(S): Hordeum vulgare 
2011-11-22 | E-GEOD-33405 | biostudies-arrayexpress
TranscriptomicsYeast genomic expression patterns in response to deoxynivalenol
The assessment of toxicity about deoxynivalenol (DON) using yeast gene expression comparison analysis. Two yeast strains, parental BY4743 and PTC1 mutant, were used for this study. SDS was used to raise the penetration of the yeast cell membrane. Keywords: stress response Four conditions are compar...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-08 | E-GEOD-14748 | biostudies-arrayexpress
TranscriptomicsSalmonella Typhimurium: control vs. Deoxynivalenol (DON) treatment
Transcriptional profiling of log and stationary phase S. Typhimurium, comparing untreated controls with Deoxynivalenol treated samples. Each array used labelled cDNA against a common genomic DNA reference. Triplicate arrays were carried out for each of the 4 conditions: untreated log phase, untreate...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-05-20 | E-GEOD-29399 | biostudies-arrayexpress
MetabolomicsStable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture
Xenobiotics are ubiquitous in the environment and modified abundantly in the human body by phase I and II metabolism. Liquid chromatography coupled to high resolution mass spectrometry is a powerful tool to investigate these biotransformation products. Here, we present a workflow based on stable iso...
2020-04-14 | MTBLS1358 | MetaboLights
TranscriptomicsPTC1 mutant Yeast Genomic Expression Patterns in Response to deoxynivalenol
The evaluation of the toxicity of deoxynivalenol using yeast gene expressions. Yeast PTC1 mutant strain was used for this study. SDS was used to raise the penetration of the yeast cell membrane. Keywords: stress response Two conditions were compared by the gene expression profiles. Both samples wer...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-21 | E-GEOD-20378 | biostudies-arrayexpress
TranscriptomicsInfluence of Deoxynivalenol-contaminated diet on the liver gene expression of chicken.
The mycotoxin deoxynivalenol (DON) is a secondary metabolite from Fusarium species and is frequently present on wheat and other cereals. The main effects of DON are a reduction of the feed intake and reduced weight gain of broilers. At the molecular level DON binds to the 60S ribosomal subunit and i...
ORGANISM(S): Gallus gallus 
2011-11-05 | E-GEOD-25185 | biostudies-arrayexpress
ProteomicsThe effect of Fusarium culmorum infection and deoxynivalenol (DON) application on proteome response in barley cultivars Chevron and Pedant
The effect of an artificial infection with Fusarium culmorum and an application of deoxynivalenol (DON) on barley spikes of cultivars Chevron and Pedant during flowering was investigated at grain mid-dough stage 10 days after pathogen inoculation (10 dai). Proteomic analysis using a two-dimensional ...
ORGANISM(S): Fusarium culmorum Hordeum vulgare (Barley) 
2017-09-07 | PXD006432 | Pride
Fusarium head blight  barley  fusarium culmorum  deoxynivalenol  stress-related proteins  storage proteins 
TranscriptomicsYeast Genomic Expression Patterns in Response to glucosylated mycotoxin
The evaluation of mycotoxicity about glucosylated mycotoxin using yeast gene expression comparison analysis. Yeast BY4743 derivative PDR5 mutant was used for this study. Samples were normalized with the three replicates per condition. Yeast strain was grown in YPD medium with 80 μM of deoxynivaleno...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-01 | E-GEOD-63663 | biostudies-arrayexpress
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