Sort   by:  
 Page size 
TranscriptomicsGene expression profiling of right atrium and left ventricle
A comparison of human cardiac gene expression profile in paired samples of right atrium and left ventricle extracted in vivo

ORGANISM(S): Homo sapiens 
2012-01-30 | E-MEXP-3396 | biostudies-arrayexpress
MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
TranscriptomicsTranscription profiling of feft ventricle in three genetic rat models of hypertension
Left ventricle gene expression was analyzed in three models of hypertension in order to clarify the molecular mechanisms associated with left ventricular hypertrophy. Transgenic heterozygous TGR(mRen2)27 rats, overexpressing the mouse renin gene, and their littermate negative controls, spontaneously...
ORGANISM(S): Rattus norvegicus 
2006-08-31 | E-MEXP-357 | biostudies-arrayexpress
MetabolomicsUntargeted Metabolomic Profiling of Left Ventricular Myocardium in a Mouse Model of Diabetic Cardiomyopathy
This study characterizes metabolic alterations in the left ventricular myocardium of a high-fat diet and streptozotocin-induced mouse model of diabetic cardiomyopathy. Untargeted LC–MS/MS metabolomics was performed using a Vanquish UHPLC system coupled to an Orbitrap Exploris 120 mass spectrometer. ...
2026-07-20 | MTBLS15043 | MetaboLights
TranscriptomicsTranscriptional profiling of left ventricle and peripheral blood cells in rats with post-myocardial infarction
Myocardial infarction (MI) often results in left ventricular (LV) remodeling followed by heart failure (HF). It is of great clinical importance to understand the molecular mechanisms that trigger transition from compensated LV injury to HF and to identify relevant diagnostic biomarkers. In this stud...
ORGANISM(S): Rattus norvegicus 
2013-11-15 | E-GEOD-47495 | biostudies-arrayexpress
TranscriptomicsDistinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle
MicroRNAs (miRNAs) are single-stranded non-coding RNAs that negatively regulate target gene expression through mRNA cleavage or translational repression. There is mounting evidence that they play critical roles in heart disease. The expression of known miRNAs in the heart has been studied at length ...
ORGANISM(S): Rattus norvegicus 
2014-03-28 | E-GEOD-56300 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of models of cardiac remodelling: myocardial infarction or transverse aortic constriction in left ventricle free wall and septum
We employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo models of cardiac remodeling and in two different regions (left ventricle free wall and septum) of the heart. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI)...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-415 | biostudies-arrayexpress
TranscriptomicsEffects of vitamin A on ventricular myocardium gene expression [left ventricle]
LRAT knockout mice on vitamin A sufficient or deficient diets were compared to age and gender matched wildtype mice on a vitamin A sufficient diet RNA was isolated from the left ventricle of the heart and one array was run for each sample.
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-74904 | biostudies-arrayexpress
TranscriptomicsCardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation
Each heart was assigned to one of the following three conditions: phasic systolic overload (SO), phasic diastolic overload (DO), and no loading throughout the cardiac cycle (control; CN). We created SO by isovolumic contraction (peak systolic LVP > 170 mmHg) at a constant diastolic volume with end-d...
ORGANISM(S): Rattus norvegicus 
2013-02-07 | E-GEOD-44108 | biostudies-arrayexpress
TranscriptomicsThymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation
A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA m...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-43435 | biostudies-arrayexpress
Sort   by:  
 Page size