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ProteomicsIdentification of Long Lived Synaptic Proteins by Comprehensive Proteomic Analysis of Synaptosome Protein Turnover
Memory formation is believed result from changes in synapse strength and structure. While memories may persist for the lifetime of an organism, the proteins and lipids that make up synapses undergo constant turnover with lifetimes from minutes to days. The molecular basis for memory maintenance may ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-03-19 | PXD007156 | Pride
Protein turnover Long lived protein Synaptosome 
ProteomicsLong-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases
Protein turnover, the result of protein synthesis and degradation, is an important mechanism to preserve cellular integrity. The majority of cellular proteins are broken down over a period of hours to weeks to prevent a buildup of proteins that lose their function due to damage caused by misfolding,...
ORGANISM(S): Mus Musculus 
2024-03-21 | PXD050843 |
ProteomicsIdentification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain
In order to combat molecular damage, most cellular proteins undergo rapid turnover. We have previously identified large nuclear protein assemblies that can persist for years in post-mitotic tissues and are subject to age-related decline. Here we report that mitochondria can be long-lived in the mous...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-04 | PXD028963 | Pride
Mitochondria  protein homeostasis  long-lived proteins  electron transport chain 
ProteomicsIdentification of long-lived proteins retained in cells undergoing repeated asymmetric divisions
To identify long-lived proteins that are retained in yeast mother cells, we combined a method developed in our lab with a pulse-chase protocol using total proteome analysis. Cells were initially grown in medium with stable heavy-isotope amino acids to label proteins. The cells were then switched int...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-09-01 | PXD001251 | Pride
Silac Replicative aging Saccharomyces cerevisiae 
ProteomicsIdentification of proteins synthesized from long-lived mRNAs during seed germination in rice
To identify the proteins synthesized from long-lived mRNAs at early phase of germination, proteome of embryos at 0 DAI (dry embryos), 1 DAI with α-amanitin and 1 DAI without α-amanitin were analyzed by using LC-MS/MS.
ORGANISM(S): Oryza sativa (Rice) 
2019-08-13 | PXD013628 | Pride
Α-amanitin Imbibition Embryo Rice 
ProteomicsLong-lived mitochondrial cristae proteins in mouse heart and brain
Long-lived proteins (LLPs) have recently emerged as vital components of intracellular structures whose function is coupled to long-term stability. Mitochondria are multifaceted organelles and their function hinges on the efficient proteome renewal and replacement. Here, using metabolic stable isotop...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-06-28 | MSV000087712 | MassIVE
TranscriptomicsTime-course gene expression profiles of a Saccharomyces cerevisiae wild type and long-lived sch9-delta mutant
The SCH9 null strain has smaller cell size, grows at a slower rate and survives three times longer than wide-type yeast. This study aims to dissect the mechanisms that lead to the yeast life span extension of sch9-delta. We measure gene expression profiles of the S. cerevisiae wild type and the lon...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-24 | E-GEOD-14227 | biostudies-arrayexpress
UnknownIdentification of long-lived proteins retained in cells undergoing repeated asymmetric divisions.
Not available
S-EPMC4191815 | biostudies-literature
UnknownCleavage C-terminal to Asp leads to covalent crosslinking of long-lived human proteins.
Not available
S-EPMC9227964 | biostudies-literature
ProteomicsGcn4-dependent translation reduction in long-lived ribosomal protein deletion strains
Deletion of several ribosomal proteins genes (RPKOs) has been shown to extend the lifespan of Saccharomyces cerevisiae in a Gcn4-dependent manner. To characterize the underlying mechanisms, we systematically analyzed the gene expression of both short- and long-lived RPKO strains at multiple levels. ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-07-06 | PXD004760 | Pride
Tmt Gnc4 Yeast Aging 
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