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TranscriptomicsDendritic cell maturation by proinflammatory TNF or pathogenic Trypanosoma brucei antigens instruct similar T helper-2 cell responses in murine models of autoimmunity and asthma
Background Dendritic cells (DC) represent the major cell type leading to polarized T helper (Th) cell responses in vivo. The current data indicate that DC maturation under inflammatory conditions or by helminth infections induce only incomplete DC maturation bearing a partially tolerogenic potential...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-28231 | biostudies-arrayexpress
TranscriptomicsThe histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation
The chromatin modifying enzymes that drive the erythroid-specific transcription program are incompletely understood. Setd8 is the sole histone methyltransferase in mammals capable of generating mono-methylated histone H4 lysine 20 (H4K20me1) and is expressed at significantly higher levels in erythro...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-62647 | biostudies-arrayexpress
ProteomicsSomatic embryogenesis of Pinus nigra
There are several issues complicating somatic embryogenesis in conifers, for instance the low initiation frequency, the weak maturation capacity, and the loss of an embryogenic potential after a prolonged cultivation. The aim of our study was to clarify molecular details of the this process in the t...
ORGANISM(S): Pinus nigra 
2017-09-06 | PXD004611 | Pride
Cell wall biosynthesis  conifers  embryogenic tissue  loss of maturation capacity  non-embryogenic callus  2-d gel electrophoresis 
TranscriptomicsPax5 restoration in a mouse model of B progenitor acute lymphoblastic leukemia
Hypomorphic mutations of PAX5 occur in one third of B-progenitor acute lymphoblastic leukemias (B-ALLs), however their functional consequences remain undefined. Here we employ advanced transgenic RNAi in mice to suppress endogenous Pax5 expression in the hematopoietic compartment in vivo, which co-o...
ORGANISM(S): Mus musculus 
2014-06-18 | E-GEOD-52870 | biostudies-arrayexpress
ProteomicsDynamic sperm proteome remodelling during epididymal maturation in a marsupial, Macropus giganteus
While assisted reproductive technologies (ARTs) are widely used in domestic animals, successful implementation of ARTs to conserve wildlife species remains challenging. In macropods, crucial aspects of fundamental reproductive biology, including changes induced by epididymal maturation, remain unkno...
ORGANISM(S): Macropus giganteus 
2025-09-29 | PXD064577 | Pride
Epididymal Sperm Kangaroo Marsupial Macropod Epididymis Spermatozoa 
GenomicsReprogramming-associated aberrant DNA methylation determines hematopoietic differentiation capacity of human induced pluripotent stem cells
The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryoni...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-74967 | biostudies-arrayexpress
GenomicsEpigenetic analysis of perinatal maturation of supporting cells in the organ of Corti
Epigenetic analysis of perinatal maturation of supporting cells in the organ of Corti
PRJNA630758 | ENA
UnknownThe Trypanosoma brucei gambiense secretome impairs lipopolysaccharide-induced maturation, cytokine production, and allostimulatory capacity of dendritic cells.
Not available
S-EPMC3754197 | biostudies-literature
TranscriptomicsMultifaceted maturation of monocyte-derived dendritic cells stimulated by intracellular bacteria
Background: It has been shown that intracellular pathogens hijack DC functions to evade immune defense mechanisms. In this study, we investigated the responses of human monocyte derived DCs to four intracellular bacteria, Tropheryma whipplei, Coxiella burnetii, Brucella abortus and Orientia tsutsuga...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-49016 | biostudies-arrayexpress
ProteomicsProteomic phenotyping of stimulated Müller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity
Müller cells are the main macroglial cells of the retina exerting a wealth of functions to maintain retinal homoeostasis. Upon pathological changes in the retina, they become gliotic with both protective and detrimental consequences. Accumulating data also provide evidence for a pivotal role of Müll...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-02-16 | PXD028390 | Pride
Pro-inflammatory Complement system Cytokines. retina Immune response Müller cells Atypical antigen-presenting cell Diabetic retinopathy 
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