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ProteomicsExploring the spatial distribution of biomolecules in Pseudomonas aeruginosa biofilms formed on PDMS and lung explants by mass spectrometry imaging
Bacterial biofilms constitute a form of collective organization that enhances bacterial tolerance to both antibiotics and immune defences. Among bacteria, Pseudomonas aeruginosa is a major opportunistic pathogen, with marked biofilm-forming capacity, highly implicated in chronic pulmonary infections...
ORGANISM(S): Mus musculus (Mouse) Pseudomonas aeruginosa PA14 Pseudomonas aeruginosa PAO1-GFP 
2026-10-26 | PXD079719 | Pride
Pseudomonas aeruginosa  bacterial biofilm  mass spectrometry imaging (msi)  polydimethylsiloxane (pdms)  lung explant. 
TranscriptomicsscRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue
Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition ...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10662 | biostudies-arrayexpress
GenomicsSpatial transcriptomic comparison between IPF and donor lung distal explant tissue
Spatial transcriptomic comparison between IPF and donor lung distal explant tissue
PRJNA1242230 | ENA
TranscriptomicsscRNA-seq of canalicular stage human fetal lung cultured under air-liquid interface
Small pieces (<0.5 cm of diameter) were isolated from distal regions of 125 day male human fetal lung and cultured on floating poly-carbonate membranes on top of serum and growth factor free medium under air-liquid interface conditons (ALI). ALI explants underwent changes in gene expression indicati...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-12959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetal lung epithelial cells in undifferentiated state and after type II cell differentiation induced by DCI treatment
Studies of human fetal lung in explant culture and in isolated epithelial cells have demonstrated that both glucocorticoids and cyclic AMP promote differentiated alveolar type II cell phenotype as assessed by ultrastructural morphology and surfactant production. This project profiles changes in gen...
ORGANISM(S): Homo sapiens 
2007-11-22 | E-GEOD-3306 | biostudies-arrayexpress
UnknownProtocol to study early lung developmental branching in mouse embryos using explant culture.
Not available
S-EPMC11315079 | biostudies-literature
TranscriptomicsValidated Gene Expression Signatures of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease that is difficult to diagnose and follows an unpredictable clinical course. The object of this study was to develop a predictive gene signature model of IPF from whole lung tissue. We collected whole lung samples from 11 IPF pat...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-24206 | biostudies-arrayexpress
TranscriptomicsEffects of dexamethasone on cultured lung explant
The lung is a branched tubular network with two distinct compartments — the proximal conducting airways and the peripheral gas exchange region — separated by a discrete boundary termed the bronchoalveolar duct junction (BADJ). Here we image the developing mouse lung in three-dimensions and show th...
ORGANISM(S): Mus musculus 
2014-05-22 | E-GEOD-56831 | biostudies-arrayexpress
TranscriptomicsCole Lab Fred- genotypeRA experiment
Mammalian lung development during the saccular and alveolar stages is dependent upon antagonistic molecular signalling by endogenous retinoic acid (RA) and glucocorticoids (GCs) which regulate gene expression via the retinoic acid receptor (RAR) family and the glucocorticoid receptor (GR), respectiv...
ORGANISM(S): Mus musculus 
2014-01-12 | E-MEXP-3833 | biostudies-arrayexpress
UnknownClinical predictors and explant lung pathology of acute exacerbation of idiopathic pulmonary fibrosis.
Not available
S-EPMC7533375 | biostudies-literature
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