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ProteomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
This study investigates the role of cancer cell surface proteins in modulating the response of cancer cells to macrophage-induced cytotoxicity. Utilizing two targeted CRISPR screens using OVCAR-8 cell line and a targeted CRISPR library for cancer cell surface proteins, ATG9A was identified as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053872 | Pride
Atg9a  macrophage-mediated cytotoxicity  crispr screens  cancer cell surface proteins 
GenomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
Co-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
PRJNA1106773 | ENA
UnknownExploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.
Not available
S-EPMC12216399 | biostudies-literature
TranscriptomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
This study investigates the role of cancer cell surface proteins in modulating the response of cancer cells to macrophage-induced cytotoxicity. Utilizing two targeted CRISPR screens using OVCAR-8 cell line and a targeted CRISPR library for cancer cell surface proteins, ATG9A was identified as a key ...
ORGANISM(S): Mus musculus Homo sapiens 
2025-04-30 | GSE266329 | GEO
ModelsSmith2011 - Three Stage Innate Immune Response to a Pneumococcal Lung Infection
Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease. We combine bacterial titer measurements from mice infected with Streptococcus pneumoniae with math...
2024-09-02 | BIOMD0000000924 | BioModels
UnknownTumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity.
Not available
S-EPMC6064871 | biostudies-literature
UnknownFlagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.
Not available
S-EPMC1401497 | biostudies-literature
UnknownSilica nanocarrier-mediated intracellular delivery of rapamycin promotes autophagy-mediated M2 macrophage polarization to regulate bone regeneration.
Not available
S-EPMC10106556 | biostudies-literature
UnknownMETTL3/RBM15 augments the stability of Kdm6b mRNA and promotes STAT1-mediated macrophage activation and atherosclerosis.
Not available
S-EPMC12800227 | biostudies-literature
UnknownCrushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy.
Not available
S-EPMC7770679 | biostudies-literature
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