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TranscriptomicsUpregulation of Expression of Matrix Metalloproteinases in Alveolar Macrophages of HIV1+ Smokers with Early Emphysema
HIV1+ smokers develop emphysema at an earlier age and with a higher incidence than HIV1- smokers. Based on the knowledge that human alveolar macrophages (AM) are capable of producing proteases that degrade extracellular matrix components, we hypothesized that upregulation of AM matrix metalloprotein...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-10038 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C57Bl6 MMP-7 and MMP-10 deficient mice Pseudomonas aeruginosa exposed airway epithelium.
Airway epithelium is the initial point of host-pathogen interaction in Pseudomonas aeruginosa infection, an important pathogen in cystic fibrosis and nosocomial pneumonia. We used global gene expression analysis to determine airway epithelial transcriptional responses dependent on matrilysin (MMP-7)...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7957 | biostudies-arrayexpress
UnknownTissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9.
Not available
S-EPMC10843048 | biostudies-literature
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
GenomicsThe gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development
The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development
PRJNA928102 | ENA
GenomicsDysregulation of cell migration by matrix metalloproteinases in geleophysic dysplasia
Dysregulation of cell migration by matrix metalloproteinases in geleophysic dysplasia
PRJNA1240284 | ENA
UnknownMatrix metalloproteinases in emphysema.
Not available
S-EPMC6377072 | biostudies-literature
TranscriptomicsTranscription profiling of human acne lesion vs. normal skin from acne and non acne patients
The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. In an attempt to understand the specific genes involved in inflammatory acne, we performed gen...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6475 | biostudies-arrayexpress
ClinicalMatrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research trial is studying ma...
2072126 | ecrin-mdr-crc
TranscriptomicsMulti-component epigenetic control of pro-invasive genes in cancer cells (miRNA)
To identify the epigenetic signature that controls cancer cell migration, we performed integrated gene expression, miRNA and epigenetic profiling of 486 selected invasion-associated genes in non-migratory MCF-7 breast carcinoma and highly migratory U251 glioma cells. We used a custom-built chromatin...
ORGANISM(S): Homo sapiens 
2010-01-05 | E-GEOD-18894 | biostudies-arrayexpress
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