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ProteomicsMCM8 interacts with DDX5 to promote R-loop resolution in primordial germ cells
MCM8 has emerged as a core gene in reproductive aging and is crucial for meiotic homologous recombination repair. It also safeguards genome stability by coordinating the replication stress response during mitosis, but its function in mitotic germ cells remains elusive. Here we found that the number ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-31 | PXD050727 | Pride
Primordial germ cells  mcm8  r-loop  genome stability  fertility 
ProteomicsMCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially i...
ORGANISM(S): Homo sapiens (Human) 
2020-06-15 | PXD019156 | Pride
C17orf53 Mcm9 Mcm8 Mcm8ip Cisplatin Rpa Homologous recombination 
GenomicsEffect of MCM8 deficiency on gene expression of mouse embryo fibroblasts
Effect of MCM8 deficiency on gene expression of mouse embryo fibroblasts
PRJNA1068097 | ENA
GenomicsCUT&TAG analysis of R-loops in Mcm8 knockout MEFs and CUT&TAG analysis of R-loops and MCM8-binding sites in HEK293 cells
CUT&TAG analysis of R-loops in Mcm8 knockout MEFs and CUT&TAG analysis of R-loops and MCM8-binding sites in HEK293 cells
PRJNA1070001 | ENA
GenomicsCUT&TAG analysis of R-loops in Mcm8 knockout MEFs and CUT&TAG analysis of R-loops and MCM8-binding site in HEK293 cells
CUT&TAG analysis of R-loops in Mcm8 knockout MEFs and CUT&TAG analysis of R-loops and MCM8-binding site in HEK293 cells
PRJNA1003015 | ENA
TranscriptomicsEffect of MCM8 deficiency on gene expression of mouse embryo fibroblasts
MCM8 is essential in the replication stress response to maintain genome stability during mitosis. The deficiency of MCM8 results in impaired proliferation and a prolonged cell cycle, which can decrease cell populations. To investigate the effect of MCM8 deficiency on gene expression, we conducted th...
ORGANISM(S): Mus musculus 
2024-05-30 | GSE254004 | GEO
GenomicsCUT&TAG analysis of R-loops in Mcm8 knockout MEFs and CUT&TAG analysis of R-loops and MCM8-binding site in HEK293 cells
To reveal the role of MCM8 in suppressing R-loop accumulation, we performed the CUT&TAG assay using the S9.6 antibody to map genome-wide R-loops in MEFs derived from Mcm8 knockout and wildtype embryos. To investigate the underlying molecular mechanism of MCM8 suppressing R-loops, we conducted the DN...
ORGANISM(S): Mus musculus Homo sapiens 
2026-08-07 | GSE240230 | GEO
GenomicsCUT&TAG analysis of R-loops in Mcm8 knockout MEFs and CUT&TAG analysis of R-loops and MCM8-binding sites in HEK293 cells
To reveal the role of MCM8 in suppressing R-loop accumulation, we performed the CUT&TAG assay using the S9.6 antibody to map genome-wide R-loops in Mcm8 wildtype MEFs and Mcm8 knockout MEFs. We also conducted the CUT&TAG assay to detect genome-wide R-loops in Ddx5 downregulated MEFs by adenovirus in...
ORGANISM(S): Mus musculus Homo sapiens 
2024-05-30 | GSE254352 | GEO
GenomicsMCM8 mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease
MCM8 mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease
PRJNA988142 | ENA
TranscriptomicsMCM8 mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease
Mitophagy is a major quality control pathway that removes unwanted or dysfunctional mitochondria, and plays an essential role in vascular health. Here we show that MCM8 expression is significantly decreased in children with Kawasaki disease (KD) who developed coronary artery aneurysms. Mechanistical...
ORGANISM(S): Mus musculus 
2023-06-29 | GSE235994 | GEO
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