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Metabolomics, as a high-throughput analytical technique, enables comprehensive analysis of the metabolic changes in microorganisms under different environmental conditions, revealing the molecular basis of their antibacterial mechanisms. This study employs metabolomics analysis to investigate the an...
2025-04-25 | MTBLS11717 | MetaboLights
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights

BACKGROUND: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved.

RESULTS: We investigate color morph-enriched Asian vine snakes...

2023-02-23 | MTBLS6927 | MetaboLights

This study investigates lipid dysregulation in calcific aortic valve stenosis (CAVS) by analyzing lipid profiles in valve tissues from 99 patients across different disease severities (mild, moderate, severe) using liquid chromatography-mass spectrometry (LC-MS). The results reveal distinct lipid ...

2025-06-25 | MTBLS6622 | MetaboLights

The pathogenic mechanisms of many diseases are well understood at the molecular level, but there are prevalent diseases associated with pathogenic signaling, such as diabetes and chronic inflammatory disorders, where our understanding is more limited. Here we report that pathogenic signaling supp...

2024-08-09 | MTBLS9535 | MetaboLights

Processive catalysis is a fundamental molecular mechanism in nature to both build and dismantle complex biological polymers such as nucleic acids, proteins and carbohydrates, underpinning a broad spectrum of biotechnological applications. Here, we uncover a processive mechanism for the breakdown ...

2026-03-02 | MTBLS13959 | MetaboLights

Exploring the mechanism of YJW's antidepressant effect based on multi omics analysis.

Exploring the mechanism of YJW's antidepressant effect based on multi omics analysis

Exploring the mechanism of YJW's antidepressant effect based on multi omics analysis

2026-10-05 | MTBLS15921 | MetaboLights
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