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GenomicsDiabetes induced microbiome dysbiosis is associated with therapy resistance in Pancreatic Ductal Adenocarcinoma (PDAC)
Pancreatic cancer is the 3rd most prevalent cause of cancer related deaths in United states alone, with over 55000 patients being diagnosed in 2019 alone and nearly as many succumbing to it. Late detection, lack of effective therapy and poor understanding of pancreatic cancer systemically contribute...
ORGANISM(S): mouse gut metagenome 
2020-11-30 | E-MTAB-8739 | biostudies-arrayexpress
GenomicsGut microbiome modulates response to anti PD1 immunotherapy in metastatic melanoma patients
There is a growing appreciation of the role of the microbiome in cancer, and evidence in pre-clinical models that the gut microbiome may modulate responses to immune checkpoint blockade though this has not been well-characterized in patients. We analyzed the oral (n=86)and gut (n=43) 16S microbiome ...
EGAS00001002698 | EGA
ProteomicsEffect of Edurans secretome of human microbiome
A rapid ex vivo microbiome assay and metaproteomics approach was used for evaluating the impacts of E. durans derived secretome on a human gut microbiome cultured in vitro.
ORGANISM(S): metagenome 
2024-01-31 | PXD040751 | Pride
Probiotics Microbiome Metaproteomics 
ProteomicsRapid Assay of Individual Microbiome responses to drugs data part2
We developed an approach named Rapid Assay of Individual Microbiome (RapidAIM) to screen xenobiotics against individual microbiomes. To evaluate technical reproducibility, we tested 43 compounds against an individual's microbiome. The individual microbiome is cultured in triplicates in 96-well plate...
ORGANISM(S): Escherichia coli 
2020-05-27 | PXD012725 | Pride
In vitro culture Drug Microbiome Metaproteomics 
TranscriptomicsThe Dynamics of the Vaginal Microbiome During Infertility Therapy with In Vitro Fertilization-Embryo Transfer
Clinical treatment protocols for infertility with in vitro fertilization-embryo transfer (IVF-ET) provide a unique opportunity to assess the human vaginal microbiome in defined hormonal milieu. Herein, we have investigated the association of circulating ovarian-derived estradiol (E2) and progesteron...
ORGANISM(S): microbiome 
2011-10-24 | E-MEXP-2958 | biostudies-arrayexpress
ProteomicsRapid Assay of Individual Microbiome responses to drugs part1
We developed an approach named Rapid Assay of Individual Microbiome (RapidAIM) to screen xenobiotics against individual microbiomes, and conducted a proof-of-concept (POC) study on the use of RapidAIM. We tested 43 compounds against five individual microbiomes. The individual microbiomes are culture...
ORGANISM(S): Escherichia coli 
2020-05-26 | PXD012724 | Pride
Drug Microbiome Metaproteomics In vitro culturing 
ProteomicsEffects of SAHA on human gut microbiome
The human stool samples were collected and processed for in vitro culturing under anaerobic condition using rapidAIM assay with or without SAHA, an lysine deacetylase inhibitor, for evaluating the effects of SAHA on human gut microbiome. Metaproteomics were used to analyze the microbiome composition...
ORGANISM(S): gut metagenome 
2022-03-01 | PXD016388 | Pride
Metaproteomics Microbiome 
GenomicsEffect of morphine treatment on microbiome in the context of microbial transplant.
Morphine causes microbial dysbiosis. In this study we focused on restoration of native microbiota in morphine treated mice and looked at the extent of restoration and immunological consequences of this restoration. Fecal transplant has been successfully used clinically, especially for treating C. di...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3723 | biostudies-arrayexpress
ProteomicsEvaluate gut microbiome biobanking
A rapid ex vivo microbiome assay and metaproteomics approach was used for rapid evaluation of the cultivability of bio-banked live microbiota, which shows minimal detrimental influences of long-term freezing in deoxygenated glycerol buffer on the cultivability of fecal microbiota.
ORGANISM(S): human gut metagenome 
2022-02-16 | PXD028857 | Pride
Freezing Microbiome Biobanking Metaproteomics 
ProteomicsBile acid dehydroxylation by the gut microbiome
A metabolic pathway for bile acid dehydroxylation by the gut microbiome
ORGANISM(S): Clostridium (ncbitaxon:1485) 
2020-03-02 | MSV000085048 | MassIVE
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