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UnknownFunctional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Not available
S-EPMC7599066 | biostudies-literature
ProteomicsMenin-MLL inhibitors enhance AP-1 transcription factor JUND activity in MLLr leukemic cells which contributes to tumorigenesis and therapy resistance (sampleIDs - EO265_276; MOLM13 cell lines)
Background: MLL-rearranged (MLLr) acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) involve reciprocal oncogenic translocations of the KMT2A/KMT2B (MLL1/MLL2) gene on chromosome 11q23 with various translocation partner genes, which yields to chimeric MLL fusion proteins (MLL-FPs). Menin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD068124 | Pride
Menin  jund  chromatin modifiers  epigenetic  mllr leukemia  vtp-50469 
ProteomicsMenin-MLL inhibitors enhance AP-1 transcription factor JUND activity in MLLr leukemic cells which contributes to tumorigenesis and therapy resistance (sampleIDs - EO85_120; HeLa cell lines)
Background: MLL-rearranged (MLLr) acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) involve reciprocal oncogenic translocations of the KMT2A/KMT2B (MLL1/MLL2) gene on chromosome 11q23 with various translocation partner genes, which yields to chimeric MLL fusion proteins (MLL-FPs). Menin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD068061 | Pride
Menin  jund  chromatin modifiers  epigenetic  mllr leukemia  vtp-50469 
ProteomicsMenin-MLL inhibitors enhance AP-1 transcription factor JUND activity in MLLr leukemic cells which contributes to tumorigenesis and therapy resistance (sampleIDs - EO01_85; HeLa cell lines)
Background: MLL-rearranged (MLLr) acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) involve reciprocal oncogenic translocations of the KMT2A/KMT2B (MLL1/MLL2) gene on chromosome 11q23 with various translocation partner genes, which yields to chimeric MLL fusion proteins (MLL-FPs). Menin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD068056 | Pride
Menin  jund  chromatin modifiers  epigenetic  mllr leukemia  vtp-50469 
ProteomicsMenin-MLL inhibitors enhance AP-1 transcription factor JUND activity in MLLr leukemic cells which contributes to tumorigenesis and therapy resistance (sampleIDs - EO241-EO252; MV-411 cell lines)
Background: MLL-rearranged (MLLr) acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) involve reciprocal oncogenic translocations of the KMT2A/KMT2B (MLL1/MLL2) gene on chromosome 11q23 with various translocation partner genes, which yields to chimeric MLL fusion proteins (MLL-FPs). Menin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD067825 | Pride
Menin  jund  chromatin modifiers  epigenetic  mllr leukemia  vtp-50469 
ProteomicsQuantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.
We describe the proteomic composition of the secretome of fetal and adult hematopoietic progenitors during MLL-rearranged (MLLr) leukemia initiation as well as the pre-leukemic cells’ secretion response to the treatment with Fibulin (Fbln1) and/or Fibronectin (Fn1) using data-independent acquisition...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD049014 | Pride
Bone marrow Leukemia Secretome Extracellular Fetal liver Data-independent acquisition Hematopoietic progenitors 
UnknownNG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.
Not available
S-EPMC6755967 | biostudies-literature
GenomicsThree-dimensional chromatin landscapes in MLLr AML [RNA-Seq]
Three-dimensional chromatin landscapes in MLLr AML [RNA-Seq]
PRJNA1023238 | ENA
GenomicsThree-dimensional chromatin landscapes in MLLr AML [Micro-C]
Three-dimensional chromatin landscapes in MLLr AML [Micro-C]
PRJNA1023239 | ENA
ProteomicsQuantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia
Infant and adult MLL-rearranged (MLLr) leukemia represents a disease with few treatment options and a dismal prognosis. Here, we present an in-depth proteomic characterization of in utero-initiated and adult-onset MLLr leukemia in a mouse model of MLL-ENL-mediated leukemogenesis. We characterize ear...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042249 | Pride
Adult hematopoietic progenitor Tmtpro Mll-rearranged leukemia Fetal hematopoietic progenitor 
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