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MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsAlterations in the metabolic footprint induced by Mayaro virus infection in cell culture
This study focuses metabolic footprinting of Vero cells infected by Mayaro virus. Nuclear magnetic resonance combined with multivariate analytical methods and tools of pattern recognition shows that metabolic changes can be attributed to the effect of Mayaro virus infection. Vero cells infected by M...
2021-10-28 | MTBLS639 | MetaboLights
TranscriptomicsNeural induction (N2B27 monolayer cluture)
Neural induction of ES by N2B27 monolayer culture Neural induction of ES by N2B27 monolayer culture
ORGANISM(S): Mus musculus 
2006-01-22 | E-GEOD-4076 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Pluripotent Stem Cell-Derived Endometrial Stromal Fibroblasts in Monolayer Differentiation and in Co-culture with Endometrial Epithelial Organoids
H9 Pluripotent Stem Cells (PSC) were differentiated to Endometrial Stromal Fibroblasts (PSC-ESF) in monolayer over the course of 12 days. Gene expression was measured at day 0, day 4, day 8, and day 12 of differentiation. At day 12, PSC-ESF were dissociated from monolayer culture for co-culture with...
ORGANISM(S): Homo sapiens 
2021-05-05 | E-MTAB-10375 | biostudies-arrayexpress
TranscriptomicsComparison of spheroid-based 3-dimensional culture to monolayer of larynx carcinoma cell line HLaC78.
In vitro proliferation and/or invasion tests (such as MTT assay, Boyden Chamber Assay, Scratch assay) using established and well-characterized cell lines can provide easy and reproducible tools to investigate anti-tumour or anti-invasion agents ex vivo. However, in vivo cells in a tissue context int...
ORGANISM(S): Homo sapiens 
2016-03-11 | E-GEOD-67495 | biostudies-arrayexpress
TranscriptomicsA Comparative Study of Genome Wide Transcriptional Profiles of Primary Hepatocyte in In Vitro Cultures
The liver is one of most important organs in our bodies. It performs many essential functions including metabolism, synthesis, secretion, detoxification, and storage. Hepatocytes are the principal cell type in the liver and are involved in multiple liver-specific functions. There have been several e...
ORGANISM(S): Rattus norvegicus 
2010-06-08 | E-GEOD-20659 | biostudies-arrayexpress
GenomicsGene expression of C28/I2 cells in monolayer and spheroid culture
Gene expression of C28/I2 cells in monolayer and spheroid culture
PRJNA931934 | ENA
ProteomicsProteome profiling of myogenic differentiation of alveolar mucosa multipotent mesenchymal stromal cells revealed an unexpected deviation between 2D monolayer and 3D spheroid model cultures.
Recently, it has been proposed to employ three-dimensional cultivation of cell in spheroids that contributes more proper physiological conditions in matrix extracellular space architecture and cell morphology accompanied by appropriate intracellular biomechanical organization of cytoskeleton and ene...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD015410 | Pride
Myogenesis  monolayer culture  spheroid culture  cytoskeleton  mitochondria  autophagy 
TranscriptomicsGenome-wide analysis of MCF-7 cells expressing or not MMP-14 (MT1-MMP) growing in monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (VEC) or human MMP-14 cDNA (MT1) in monolayer growth conditions. MCF-7 cel...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-64320 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cell neural induction (N2B27 monolayer cluture)
Neural induction of ES by N2B27 monolayer culture
ORGANISM(S): Mus musculus 
2005-01-01 | E-MNIA-64 | biostudies-arrayexpress
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