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TranscriptomicsMito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-57761 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cochlea to investigate the role of mtDNA mutations in age-related hearing loss in mice carrying a mutator DNA polymerase gamma
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related disorders. Previously, we created mice expressing a proofreading-deficient version of the mtDNA polymerase gamma (Polg) which accumulate age-related mtDNA mutations and display premature aging. Here we performed microarray g...
ORGANISM(S): Mus musculus 
2008-11-07 | E-GEOD-4866 | biostudies-arrayexpress
TranscriptomicsCells following mtDNA loss, or NAR1 repression
Expression analysis of cells the given amount of time after mtDNA was lost (or Nar1 expression was repressed) compared to pretreatment (or NAR1 being fully expressed). One time course experiment (Cells a given amount of time following mtDNA loss compared to cells with intact mtDNA), with 2 two condi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-21 | E-GEOD-15302 | biostudies-arrayexpress
TranscriptomicsInsights into N-calls of mitochondrial DNA sequencing using MitoChip v2.0
Background: Developments in DNA resequencing microarrays include mitochondrial DNA (mtDNA) sequencing and mutation detection. During automated analysis to sequence mtDNA, bases can be identified as wildtype, variant, or there may be a failure to assign a base (N-call) when compared to the mtDNA refe...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-GEOD-29550 | biostudies-arrayexpress
ProteomicsEnabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
Mitochondrial DNA (mtDNA) mutations predominantly cause neurological diseases. Searching for therapeutic strategies is hindered by the absence of viable neural model systems due to the challenges of engineering mtDNA. We demonstrate that neural progenitor cells (NPCs), rapidly obtained from human in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080849 | MassIVE
TranscriptomicsReduced protein kinase A signaling can diminish the nuclear transcriptional response to mtDNA damage in Saccharomyces cerevisiae
Damage to the mitochondrial genome (mtDNA) severely affects the cell and causes disease. Mutations to mtDNA also accumulate throughout the lifespan of many organisms and may be a proximal cause of aging. There is no effective treatment for ailments caused by mtDNA mutation. Since mitochondrial funct...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-07 | E-GEOD-71252 | biostudies-arrayexpress
ProteomicsAlovudine Targets mtDNA‑Dependent Proteins Encoded by Genes Recurrently Amplified in Metastatic Breast Cancer Cohorts
Previously, we demonstrated that high levels of mtDNA were functionally associated with “stemness” and aggressive phenotypic behaviours in human breast cancer cells, including spontaneous metastasis. More specifically, we showed that treatment with Alovudine induced mtDNA-depletion in MDA-MB-231 cel...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD077655 | Pride
Mtdna Mtdna-depletedrho(0) cells Mitochondria Alovudine Breast cancer Proteomics Metastasis 
ProteomicsMitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
Integrity of mitochondrial DNA (mtDNA), encoding several subunits of the respiratory chain, is essential to maintain mitochondrial fitness. Mitochondria, as a central hub for metabolism, are affected in a wide variety of human diseases but also during normal ageing, where mtDNA integrity is compromi...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-07 | PXD023939 | Pride
Mitophagy Twinkle Autophagy Mitochondrial nucleoid Mtdna 
ProteomicsMice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009138 | Pride
Mtdna deletions Mgme1 knock out Progeria 
ProteomicsProximity labelling of mitochondria and endosomes upon mtDNA replication stress.
This project aims to identify novel regulators of mtDNA turnover, for what we used TurboID. For specific detection of the mitochondria-endosome proteome, we fused the N-terminal part of Turbo ID to RAB5C (TurboID aa1-aa72; RAB5C-SplitTurboNt-V5) and, the C-terminal part to SAMM50 (TurboID aa73–aa246...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD049081 | Pride
Mtdna Mitochondria Turboid 
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