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MetabolomicsContribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...
2022-01-14 | MTBLS1679 | MetaboLights
MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

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2025-03-28 | MTBLS10098 | MetaboLights
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
TranscriptomicsSpecific modulation of mucosal immune response, tolerance and proliferation in mice colonized with A. muciniphila
Epithelial cells of the mammalian intestine are covered with a mucus layer that prevents direct contact with intestinal microbes but also constitutes a substrate for mucus-degrading bacteria. To study the effect of mucus degradation on the host response, germ-free mice were colonized with Akkermansi...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-18587 | biostudies-arrayexpress
GenomicsMucosal immune response against equine herpesvirus type 1
Mucosal immune response against equine herpesvirus type 1
PRJNA974455 | ENA
TranscriptomicsMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Infliximab, an anti-TNF-alpha monoclonal antibody, is an effective treatment for ulcerative colitis (UC) with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-TNF-alpha is unknown. This study used colonic mucosal gene expression to pr...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-GEOD-14580 | biostudies-arrayexpress
ModelsLeber2015 - Mucosal immunity and gut microbiome interaction during C. difficile infection
Leber2015 - Mucosal immunity and gut microbiome interaction during C. difficile infection This model is described in the article: Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection. Leber A, Viladomiu M, Hont...
2024-09-02 | BIOMD0000000583 | BioModels
ModelsCarbo2013 - Mucosal Immune Response during H.pylori Infection
Not available
2024-09-02 | BIOMD0000000480 | BioModels
TranscriptomicsMucosal responses of healthy humans to exponentially growing or stationary Lactobacillus plantarum bacteria
Some commensal bacteria stimulate the immune system but do not present specific antigenicity. Such adjuvant effects have been reported for the bacterial species Lactobacillus plantarum. To study in vivo human responses to L. plantarum, a randomised double-blind placebo-controlled cross-over study wa...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-GEOD-11355 | biostudies-arrayexpress
TranscriptomicsPouch transcriptional differences between UC and FAP indicate altered immune response.
A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and selected patients with ulcerative colitis (UC). However, this surgical treatment often associates with a long-term complication, ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-50788 | biostudies-arrayexpress
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