Sort   by:  
 Page size 

BACKGROUND: Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we iden...

2025-10-19 | MTBLS13178 | MetaboLights
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling, and cellular phenotyping. Understanding the surfaceome of complex tissues including the heart is essential to investigate membrane composition and function in physiol...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, the transcriptional landscape of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candida...
ORGANISM(S): Mus musculus 
The type 2 diabetes medication, rosiglitazone, has come under scrutiny for possibly increasing the risk of cardiac disease and death. To investigate the effects of rosiglitazone on the diabetic heart, we performed cardiac transcriptional profiling of a murine model of type 2 diabetes, the C57BL/KLS...
ORGANISM(S): Mus musculus 
The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generate...
ORGANISM(S): Danio rerio 
Here, we report significant changes in the composition of the lung microbiome and metabolome of mice under immune suppression, infection of immunosuppressed mice with virulent and avirulent strains of the clinically important human-pathogenic fungus Aspergillus fumigatus, and treatment with the clin...
2025-07-04 | MTBLS12262 | MetaboLights
Recent clinical data suggest that the efficacy of statin treatment in patients with heart failure varies depending on the drugs administered. Therefore, the present study was undertaken to compare murine cardiac gene expression following treatment with four different statins. Statins directly regula...
ORGANISM(S): Mus musculus 
Therapeutic remodelling and repair of murine heart induced by CD14 antibody treatment. Global (apex) heart and macrophage-derived (FACS) proteome remodelling of CD14 antibody-based therapeutic.
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD041192 | Pride
This SuperSeries is composed of the following subset Series: GSE30495: Detailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart. GSE30553: Detailed transcriptomics analysis of the effect of the PPARalpha agonist Wy14,643 on gene regulation in the ...
ORGANISM(S): Mus musculus 
Sort   by:  
 Page size