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GenomicsMutant p53 cooperates with ETS2 to promote etoposide resistance
This SuperSeries is composed of the following subset Series: GSE36749: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq] GSE36751: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36752 | biostudies-arrayexpress
TranscriptomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36751 | biostudies-arrayexpress
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
TranscriptomicsPin1/mutant-p53 jointly controlled genes
To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells. MDA-MB-231 cells were transfected twice with siRNA agains...
ORGANISM(S): Homo sapiens 
2011-05-30 | E-GEOD-26262 | biostudies-arrayexpress
ProteomicsMutant p53 interactome study with IP-MS
Inactivating TP53 mutations lead to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promote tumor development and progression. The GOF activities of TP53 mutations are well documented, but the mechanisms involved remain p...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD047094 | Pride
Ms Ip Mutant p53 P53 
GenomicsTranscriptome analysis of mutant p53 (p53-V272M, p53-R282W) rescued by arsenic trioxide (ATO)
Transcriptome analysis of mutant p53 (p53-V272M, p53-R282W) rescued by arsenic trioxide (ATO)
PRJNA636976 | ENA
Proteomics26S proteasome is conserved, therapeutically relevant mediator of mutant p53 gain-of-function in cancer
Mutant p53 proteins, resulting form frequent TP53 tumor suppressor missense mutations, possess gain-of-function activities and are among the most widespread and robust oncoproteins in human tumors. They are potentially important but understudied therapeutic targets. No studies to date have distingui...
ORGANISM(S): Homo sapiens (Human) 
2016-05-03 | PXD001673 | Pride
Cancer Triple negative breast cancer (tnbc) Tp53 
GenomicsMutant IDH disables p53 tumor suppression [CUT&RUN]
Mutant IDH disables p53 tumor suppression [CUT&RUN]
PRJNA1173479 | ENA
GenomicsChIP-seq of H1299 cells stably transfected with empty vector or the p53 mutant R273H
This experiment was performed to determine which gene promoters mutant p53 binds and transcriptionally regulates in order to understand how mutant p53 accomplishes its gain of function phenotype.
ORGANISM(S): Homo sapiens 
2017-04-16 | E-MTAB-5653 | biostudies-arrayexpress
TranscriptomicsChromatin immunopreciptiation of human breast epithelial HME1 cell lines over-expressing wild type or mutant p53 to study p53 binding
p53 binding was studied using ChIP on chip technique in breast epithelial HME1 cell lines overexpressing wt or mutant p53
ORGANISM(S): Homo sapiens 
2008-10-25 | E-MEXP-1491 | biostudies-arrayexpress
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