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ProteomicsGlycoproteomics Landscape of Asymptomatic and Symptomatic Human Alzheimer's Disease Brain
Alterations of protein abundance and post-translational modifications in patients with Alzheimer’s disease (AD), such as glycosylation, phosphorylation, and ubiquitination, and their roles in disease progression and treatment outcome are areas of intense study. Little is known, however, about...
ORGANISM(S): Homo sapiens (Human) 
2022-10-31 | PXD032219 | Pride
Glycoproteins Mass spectrometry Glycoproteomics Alzheimer's 
ProteomicsN-GlycositeAtlas, a database resource for mass spectrometry-based human N-linked glycoproteins and glycosylation sites
N-Linked glycoprotein is a highly interesting class of proteins for clinical and biological research. The large-scale characterization of N-linked glycoproteins accomplished by mass spectrometry-based glycoproteomics has provided valuable insights into the interdependence of glycoprotein structure a...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD005143 | Pride
Mass spectrometry Glycoprotein Protein glycosylation Database Glycoproteome 
ProteomicsLarge scale intact glycopeptide identification by Mascot database search
We present the adaptability of Mascot search engine for automated identification of intact glycopeptide mass spectra. The steps involved in adopting Mascot for intact glycopeptide analysis include: i) assigning unique one letter codes for monosaccharides, ii) linearizing glycan sequences and iii) pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-02 | MSV000082567 | MassIVE
ProteomicsComparison of Intact Glycopeptide Enrichment Methods Using Strong Anion Exchange and Hydrophilic Interaction Liquid Chromatography
Heterogeneity of protein glycosylation poses great challenge for analysis that is key to un-puzzle systems glycobiology in diseases. Resolving this conundrum requires global enrichment of glycopeptides for identification and quantitation. To this aim, hydrophilic interaction chromatography (HILIC) h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-02 | MSV000082566 | MassIVE
ProteomicsProteome and glycoproteome analyses reveal the proteinProteome and glycoproteome analyses reveal the protein N-linked glycosylation specificity of STT3A and STT3B N-linked glycosylation specificity of STT3A and STT3B
STT3A and STT3B are the main catalytic subunit of oligosaccharyltransferase (OST-A and OST-B in mammalian cells), which primarily mediate cotranslational and posttranslocational N-linked glycosylation, respectively. To determine the specificity of STT3A and STT3B, we performed proteomics and glycopr...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD031276 | Pride
Ost Glycoproteomics，mass spectrometry 
ProteomicsGlycoProteomics in CDG (congenital disorder of glycosilation)
Critical role for high multiplicity of protein N-linked glycans in neuron adhesion
ORGANISM(S): Mus musculus (Mouse) 
2018-10-16 | PXD009906 | Pride
Proteomics Glycoproteomics Congenital disorder of glycosilation 
ProteomicsGlycoproteomics analysis of triple wild-type lung adenocarcinoma tissue samples
Glycoproteomics analysis of triple wild-type lung adenocarcinoma tissue samples for the publication of the same name.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-18 | MSV000096450 | MassIVE
ProteomicsRe-analysis of glycoproteomics data with MSFragger-Glyco
Reanalysis of submissions PXD011533 and PXD009476 using MSFragger-Glyco mode. Processed MSFragger results files (pepXML) and PSM tables (psm.tsv) supporting MSFragger-Glyco manuscript (Fast and Comprehensive N- and O-glycoproteomics analysis with MSFragger-Glyco. Recent advances in methods for enric...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-10-06 | PXD021196 | Pride
Glycosylation Glycoproteomics Msfragger Reanalysis O-glycosylation Glycan Glycopeptide N-glycosylation 
ProteomicsN-GlycositeAtlas, a database resource for mass spectrometry-based human N-linked glycoproteins and glycosylation sites
N-Linked glycoprotein is a highly interesting class of proteins for clinical and biological research. The large-scale characterization of N-linked glycoproteins accomplished by mass spectrometry-based glycoproteomics has provided valuable insights into the interdependence of glycoprotein structure a...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD005232 | Pride
Proteomics Database Mass spectrometry Human Glycoprotein Glycosylation site 
ProteomicsGlycoPCT: quantitative glycoproteomics based on pressure cycling technology reveals distinctive N-glycosylation in human liver with non-alcoholic fatty liver disease
Protein N-glycosylation plays a crucial role in the human liver, impacting key functions like hepatocyte lipid metabolism hepatocyte apoptosis, and inflammatory response. Despite its significance, the site-specific N-glycosylation patterns and their variations of liver biosy samples between healthy ...
ORGANISM(S): Homo Sapiens 
PXD053626 |
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