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ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080783 | MassIVE
ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo sapiens (Human) 
2016-06-13 | PXD003186 | Pride
Hela N-myristoyltransferase inhibition Q-exactive Spike-in silac 
UnknownQSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors.
Not available
S-EPMC8038050 | biostudies-literature
ProteomicsProfiling N-myristoyltransferase activity and inhibition in breast cancer cells (MD-MB-231) using Sortase-A labelling
We report a novel application for Sortase A (SrtA), labeling N-terminal Gly proteins across the proteome at endogenous levels. We combined SrtA labeling of whole-cell lysates with a potent and selective NMT inhibitor, delivering a method capable of quantifying changes in cellular NMT activity in mul...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD010634 | Pride
Sortase a  srta  n-myristoylation  nmt 
ProteomicsQuantitative TMT proteomics of myristoylated proteins in Trypanosoma cruzi and human cardiomyocytes during N-myristoyltransferase inhibition
This project investigates the impact of N-myristoyltransferase (NMT) inhibition on the myristoylated proteome of Trypanosoma cruzi and human cardiomyocytes in the context of Chagas disease. Human AC16 cardiomyocytes were infected with T. cruzi (CL Brener strain) and treated with the reference NMT in...
ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human) 
2026-01-26 | PXD071927 | Pride
N-myristoyltransferase N-myristoylation Tmt sixplex Orbitrap exploris 240 Chagas disease Ac16 cardiomyocytes Trypanosoma cruzi Click chemistry Quantitative proteomics Lc–ms/ms 
UnknownDesign and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Not available
S-EPMC5734605 | biostudies-literature
UnknownPeptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.
Not available
S-EPMC4224572 | biostudies-literature
UnknownStructure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
Not available
S-EPMC4211304 | biostudies-literature
UnknownStructure-guided optimization of quinoline inhibitors of <i>Plasmodium N</i>-myristoyltransferase.
Not available
S-EPMC5463734 | biostudies-literature
UnknownN-myristoyltransferase is a cell wall target in Aspergillus fumigatus.
Not available
S-EPMC4477619 | biostudies-literature
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