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ProteomicsOxygen level regulates protein N-terminal translation elongation through deoxyhypusine hydroxylation
Hypusine is a post-translational modification on eukaryotic translation initiation factor 5A (eIF5A). The last step in the biosynthesis of hypusine, deoxyhypusine hydroxylation, is an oxygen dependent reaction. Here we show that deletion of deoxyhypusine hydroxylase, Lia1, compromises yeast respirat...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD032321 | Pride
Oxygen Silac Deoxyhupusine Hypusine 
ProteomicsAltered Transcription Factor Expression Responses to Exercise in Insulin Resistance
Purpose. Insulin resistant muscle is resistant to gene expression changes induced by acute exercise. This study was undertaken to identify transcription factors that differentially respond to exercise in insulin resistance. Candidate transcription factors were identified from analysis of 5’-untransl...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023354 | Pride
Insulin resistance Skeletal muscle Exercise Gene expression Transcription factors 
ProteomicsSCN circadian proteomes of miR-132/212 KO and WT mice by super-SILAC-based quantitative mass spectrometry
To identify potential mechanisms underlying the phenotype of miR-132/212 KO mice under short photoperiods, we used quantitative mass spectrometry to analyze the SCN proteomes of miR-132/212 KO and WT mice under a 8:16 LD schedule at 4 time points, spaced 6h apart, across a 24h cycle (n=4 per time po...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-24 | PXD003635 | Pride
Mouse Scn Lc-ms/ms 
ProteomicsProteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology
The Ras-related Rap1A GTPase is implicated in pancreas β-cell insulin secretion, and is stimulated by the cAMP sensor Epac2, a guanine exchange factor and activator of Rap1 GTPase. In this study we examined the differential proteomic profiles by nanoLC-ESI-MS/MS of pancreata from C57BL/6 Rap1A-defic...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052896 | Pride
Oral glucose tolerance test  insulin tolerance test Glucose-stimulated insulin secretion Pancreas  intracellular signaling  rap1a-gtpase  gene knockout  differential expression  nanolc-esims/ms  ero1lβ expression 
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