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ProteomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
Embryonic stem cells (ESCs) exhibit gene expression heterogeneity of key pluripotency factors (e.g. Nanog), suggesting functional relevance. To systematically identify potential regulators of transcriptional variability, we integrated single-cell RNA-seq (scRNA-seq) with ChIP-seq datasets in ESCs. O...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-06 | PXD071600 | Pride
Mesc  nap1l1  dppa3  transcriptional variability  pluripotency 
GenomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
Systematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
PRJNA1311037 | ENA
TranscriptomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
Embryonic stem cells (ESCs) maintain their capacity to generate all different cell types of the developing embryo. When grown in serum, ESCs display transcriptional heterogeneity of several key pluripotency-related genes (e.g. Nanog). This transcriptional variability was suggested to support ESC plu...
ORGANISM(S): Mus musculus 
2026-08-06 | GSE306521 | GEO
UnknownA New Role of NAP1L1 in Megakaryocytes and Human Platelets.
Not available
S-EPMC9737020 | biostudies-literature
GenomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs [scRNA-seq]
Systematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs [scRNA-seq]
PRJNA1315030 | ENA
TranscriptomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs [scRNA-seq]
Embryonic stem cells (ESCs) maintain their capacity to generate all different cell types of the developing embryo. When grown in serum, ESCs display transcriptional heterogeneity of several key pluripotency-related genes (e.g. Nanog). This transcriptional variability was suggested to support ESC plu...
ORGANISM(S): Mus musculus 
2026-08-06 | GSE307254 | GEO
UnknownNAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.
Not available
S-EPMC8962469 | biostudies-literature
TranscriptomicsSomatic NAP1L1 p.D349E promotes cardiac hypertrophy through cGAS-STING-IFN signaling
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, often caused by sarcomere gene mutations, though many sporadic cases remain genetically unexplained. Here we show that the somatic variant NAP1L1 p.D349E was involved in cardiac hypertrophy in sporadic HCM patients. Throug...
ORGANISM(S): Rattus norvegicus Mus musculus 
2025-01-13 | GSE286501 | GEO
GenomicsHomo sapiens
RNAseq analysis of NAP1L1 depleted hepatocytes
PRJNA352126 | ENA
UnknownNAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.
Not available
S-EPMC8590370 | biostudies-literature
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