Sort   by:  
 Page size 
UnknownEfficacy and Safety of rAAV2-ND4 Treatment for Leber's Hereditary Optic Neuropathy.
Not available
S-EPMC4759604 | biostudies-literature
ProteomicsOptic Atrophy-associated TMEM126A is an assembly factor for the ND4-module of Mitochondrial Complex I
Mitochondrial disease is a debilitating condition with a diverse genetic aetiology. Here, we report that TMEM126A, a protein that is mutated in patients with autosomal recessive optic atrophy, participates directly in the assembly of mitochondrial complex I. Using a combination of genome editing, in...
ORGANISM(S): Homo sapiens (Human) 
2021-04-21 | PXD023136 | Pride
Assembly factor Complex i Tmem126a Mitochondria 
ProteomicsTargeted RNase H-mediated Extraction of crosslinked RBPs (TREX) for assessing region-specific NORAD lncRNA interactome
We used Targeted RNase H-mediated Extraction of crosslinked RBPs (TREX)to assess the endogenous binding partners of the ND4 segment of NORAD long noncoding RNA (lncRNA) in human HCT116 cells. Extracted proteins from RNase H digested and control cells (4 replicate per region per condition) were compa...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD045385 | Pride
Norad  nd4  lncrna  trex  rbp  rna interactome  lc-ms/ms  quantitative proteomics 
UnknownMitochondrial Diabetes Is Associated with the ND4 G11696A Mutation.
Not available
S-EPMC10296257 | biostudies-literature
TranscriptomicsGene expression profiles of hiPSC-derived retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease caused by homoplasmic mutations in complex I subunit genes, and is characterized by incomplete penetrance. The mechanism of low penetrance of complex I mutation is still largely unclear today. In this study, w...
ORGANISM(S): Homo sapiens 
2017-09-08 | GSE103619 | GEO
UnknownNuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.
Not available
S-EPMC4444999 | biostudies-literature
UnknownPolymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging.
Not available
S-EPMC5342679 | biostudies-literature
UnknownOptic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I.
Not available
S-EPMC8092609 | biostudies-literature
UnknownOptimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.
Not available
S-EPMC2556433 | biostudies-literature
UnknownGenetic diversity and phylogeography of Phlebotomus argentipes (Diptera: Psychodidae, Phlebotominae), using COI and ND4 mitochondrial gene sequences.
Not available
S-EPMC10756540 | biostudies-literature
Sort   by:  
 Page size