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Gene expression profiles in Norad+/+ and Norad-/- brains and spleens [RNA-seq]
Mass spectrometry data were processed using MSFragger via FragPipe with default parameters. For downstream analysis, Perseus was used. The MaxLFQ intensity values were log2-transformed and filtered to include only proteins detected in at least two replicates. Missing values were imputed from a norma...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD056160 | Pride
Identification of RNAs bound to PUM2 in Norad+/+ and Norad-/- brains [CLIP-seq]
Long noncoding RNA NORAD promotes epithelial mesenchymal transition progression in lung adenocarcinoma
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochondr...
ORGANISM(S): Mus musculus 
2019-02-05 | GSE121688 | GEO
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochondr...
ORGANISM(S): Mus musculus 
2019-02-05 | GSE121684 | GEO
We used Targeted RNase H-mediated Extraction of crosslinked RBPs (TREX)to assess the endogenous binding partners of the ND4 segment of NORAD long noncoding RNA (lncRNA) in human HCT116 cells. Extracted proteins from RNase H digested and control cells (4 replicate per region per condition) were compa...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD045385 | Pride
SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA
Effect of NORAD shRNA on A549 cells treated with TGF-beta
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability [RNA-seq]
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