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Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia
Novel therapeutic approaches for addressing pneumonia caused by Streptococcus pneumoniae, which exhibit resistance to standard-of-care antibiotics are greatly needed. One viable approach involves precisely stimulating innate immune defenses within the lungs. Using murine models of pneumococcal pneum...
ORGANISM(S): Mus musculus 
2024-10-11 | GSE252037 | GEO
Respiratory delivery of the Toll-like receptor 5 agonist FLAMOD, a recombinant flagellin, offers a promising approach for treating bacterial pneumonia. FLAMOD stimulates the airway epithelium, mobilizing and activating immune cells and effectors to combat infections. While previous evidences were ob...
ORGANISM(S): Sus scrofa 
2025-02-19 | GSE289859 | GEO
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