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GenomicsThe NF-kB genomic landscape in lymphoblastoid B-cells
The nuclear factor kB (NF-kB) subunits RelA, RelB, c-Rel, p50 and p52 are each critical for B-cell development and function. To systematically characterize their responses to canonical and non-canonical NF-kB pathways activity, we performed ChIP-seq analysis in lymphoblastoid B-cells. We found a su...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-55105 | biostudies-arrayexpress
TranscriptomicsRole of NF-kB in aging
To address the role of NF-kB in aging in vivo, we utilized a well-characterized system that allows inducible and site-specific inhibition of NF-kB activity in murine skin. The hormone binding domain of the mutant estrogen receptor that is responsive to 4-hydroxytamoxifen (4-OHT) was fused to a mutan...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3845 | biostudies-arrayexpress
ProteomicsFBXO7 Binds to and Increases the Expression of the p105 Subunit of NF-kB
Cell lysate from HAP1 cells were separated on several columns, the proteins were digested with trypsin and analysed on a Q Exactive HF-X instrument.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-05 | MSV000085912 | MassIVE
ModelsAhmedMobeen2021 - NF-kB Activation Model
NF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively. The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The...
2022-05-27 | MODEL2001290001 | BioModels
GenomicsImmune differentiation regulator p100 tunes NF-kB responses to TNF
Immune differentiation regulator p100 tunes NF-kB responses to TNF
PRJNA490828 | ENA
TranscriptomicsModulation of NF-kB-Dependent Gene Transcription Using Programmable DNA Minor Groove Binders
Nuclear factor kappaB (NF-kB) is a transcription factor that regulates various aspects of immune response, cell death and differentiation as well as cancer. In this study we introduce the Py-Im polyamide 1 that binds preferentially to the sequences 5'-WGGWWW-3' and 5' GGGWWW-3'. The compound is capa...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-34329 | biostudies-arrayexpress
TranscriptomicsExpression data from the mouse liver with constitutively active NF-kB
Activation of hepatic NF-kB signaling induces inflammation and ultimately fibrosis. To investigate the underlying mechanism, we used microarrays to detail the global programme of gene expression which is regulated by hepatic NF-kB signaling. We generated transgenic mice which express a constitutivel...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-28085 | biostudies-arrayexpress
GenomicsAstrocytes differentiation is modulated by the NF-KB pathway
Astrocytes differentiation is modulated by the NF-KB pathway
PRJNA483042 | ENA
GenomicsFibroblast orchestration of inflammaging via NF-kB activation
Fibroblast orchestration of inflammaging via NF-kB activation
PRJNA1375858 | ENA
TranscriptomicsSwitching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF-kB Signaling
The bacterial product lipopolysaccharide (LPS) stimulates nuclear factor kB (NF-kB) signaling, which results in the production of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), as part of the immune response. NF-kB target genes also include those encoding proteins that i...
ORGANISM(S): Mus musculus 
2014-01-14 | E-GEOD-53810 | biostudies-arrayexpress
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