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TranscriptomicsNon-targeted effects of low dose ionizing radiation act via TGF-beta to promote mammary carcinogenesis
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy), 1 and 4 weeks after exposure. Gene expression that is modified under these parameters were compared between Tgfb1 wild type and heterozygote li...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-18216 | biostudies-arrayexpress
UnknownNon-targeted effects of ionising radiation--implications for low dose risk.
Not available
S-EPMC4091999 | biostudies-literature
TranscriptomicsNon-targeted effects of low dose ionizing radiation act via TGFβ to promote mammary carcinogenesis
It is widely believed that the carcinogenic action of ionizing radiation is due to targeted DNA damage and resulting mutations, but there is also substantial evidence that non-targeted radiation effects alter epithelial phenotype and the stromal microenvironment. Activation of transforming growth fa...
ORGANISM(S): Mus musculus 
2010-03-01 | GSE18216 | GEO
TranscriptomicsDietary flaxseed- and radiation-sensitive microRNAs in murine lung
Murine lung miRNAs were profiled by rodent TaqMan OpenArray after flaxseed feeding and/or radiation exposure Lung tissue was obtained 48 hours after radiation or no exposure from three animals each: flaxseed/no radiation, flaxseed/radiation, control diet/no radiation, control diet/radiation. miRNA p...
ORGANISM(S): Mus musculus 
2014-04-29 | E-GEOD-57123 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in response to radiation treatment in human breast cancer
Treatment-related morbidities have been linked to the large post-operative treatment volumes required for external beam partial breast irradiation (PBI). Alternative PBI techniques require equipment that is not readily available. To address these issues, we designed a phase I trial utilizing widel...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-65505 | biostudies-arrayexpress
TranscriptomicsEffect of solar ultraviolet radiation on grape berry skin transcriptome
UV radiation (UV) alters secondary metabolism in the skin of Vitis vinifera L. berries, which may affect on the final composition of both, grapes and wines. We compared berry skin transcriptome and phenolic composition between Tempranillo berries grown in the presence or absence of solar UV in a mid...
ORGANISM(S): Vitis vinifera 
2014-09-09 | E-GEOD-54636 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in response to radiation treatment in breast cancer [cell lines]
Introduction: Breast radiotherapy is currently â??one size fits allâ?? regardless of breast cancer subtype (eg. luminal, basal). However, recent clinical data suggests that radiation response may vary significantly among subtypes. Therefore, current practice leads to over- or under-treatment of wom...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-59732 | biostudies-arrayexpress
TranscriptomicsSpecific, Durable and Accurate Gene Expression Signatures of Radiation Response in Mice and Humans
Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation,...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-10640 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Stress and Immune Response Pathway Transcripts and miRNAs in Normal Human Endothelial Cells Subjected to Fractionated or Single-Dose Radiation [miRNA]
While modern radiotherapy technologies can precisely deliver higher doses of radiation to tumors; thus, reducing overall radiation exposure to normal tissues, moderate dose and normal tissue toxicity still remains a significant limitation. The present study profiled the global effects on transcript ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-56824 | biostudies-arrayexpress
ProteomicsRadiation-induced bystander effect mediated by exosomes involves the replication stress in recipient cells.
Exosomes released by irradiated cells mediate radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells, yet the specific mechanism responsible for generation of chromosome lesions remains unclear. In this study, naïve FaDu head and neck cancer cells were stim...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD032143 | Pride
Bystander effect  exosomes  ionizing radiation  non-targeted effects of radiation  replication stress 
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