Sort   by:  
 Page size 
MetabolomicsA serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely dia...
2017-09-06 | MTBLS356 | MetaboLights
GenomicsLocal Translation in Nuclear Condensate Amyloid-bodies
Local Translation in Nuclear Condensate Amyloid-bodies
PRJNA692199 | ENA
ProteomicsCBX4 contributes to HIV-1 latency by forming phase-separated nuclear bodies and SUMOylating EZH2
Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a functional cure for the acquired immunodeficiency syndrome (AIDS). To develop more promising latency-reversing agents (LRAs) to efficiently reactivate the latent reservoir which is subsequently eliminated by immune surv...
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD031011 |
ProteomicsCAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
HIV-1 latency is a major obstacle to achieve a functional cure for AIDS. To eradicate the viral reservoir, one of the strategies is to specifically reactivate HIV-1-infected cells and followed by elimination with potent immune surveillance. However, present latency-reversing agents (LRAs) are quite ...
ORGANISM(S): Homo Sapiens 
2021-02-09 | PXD024172 |
MetabolomicsNMR-based metabolomic profile of hypercholesterolemic human sera: Relationship with in vitro gene expression?
Hypercholesterolaemia is considered an important cause of atherosclerotic cardiovascular disease. In a previous investigation, we demonstrated that cultured hepatoma cells treated with hypercholesterolaemic sera compared with cells treated with normocholesterolaemic sera show overexpression of mRNAs...
2020-05-26 | MTBLS1416 | MetaboLights
TranscriptomicsNuclear scaffold and matrix attachment of Aortic Adventitial Fibroblast (AoAF) chromatin
The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
2009-03-10 | E-GEOD-13792 | biostudies-arrayexpress
ProteomicsPANNEXIN-1 CHANNEL REGULATES NUCLEAR CONTENT PACKAGING INTO APOPTOTIC BODIES AND THEIR SIZE
Apoptotic bodies (ApoBDs), which are large extracullular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability. However, current limited understanding of ApoBD biology has hindered its exploration for cl...
ORGANISM(S): Homo sapiens (Human) 
2021-04-08 | PXD023988 | Pride
Pannexin 1 Apoptotic bodies Extracellular vesicles Nuclear proteins Dna Cargo sorting 
TranscriptomicsNuclear scaffold and matrix attachment of HeLa chromatin
The nuclear scaffold/matrix provides an anchor for higher order genome structure that has both structural and functional implications. Different extraction protocols, i.e., utilizing either 25 mM LIS or 2 M NaCl, isolate somewhat different protein constituents of either the nuclear scaffold or nucl...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-13774 | biostudies-arrayexpress
TranscriptomicsIdentifying chromatin associations with promyelocytic leukemia nuclear bodies using immunoTRAP
Studies using fluorescence in situ hybridization (FISH) have attempted to determine whether specific gene loci associate with promyelocytic leukemia nuclear bodies (PML NBs). Two drawbacks accompany this approach; the lack of spatial resolution inherent with the technique, and the a priori basis fo...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-40554 | biostudies-arrayexpress
TranscriptomicsEffects of the long noncoding RNA Malat1 on gene expression [Mouse430_2]
Malat1 is an abundant long noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing factors. Previous in vitro studies have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich ...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-37705 | biostudies-arrayexpress
Sort   by:  
 Page size