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ProteomicsMatrisome remodelling during Intervertebral Disc development and ageing
Intervertebral disc (IVD) is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. Although the changes that occur with ageing in the IVD have been under study, no...
ORGANISM(S): Bos taurus (Bovine) 
2017-09-25 | PXD004922 | Pride
Intervertebral disc (ivd)  extracellular matrix (ecm)  nucleus pulpous (np)  itraq 
UnknownTherapeutic potential of melatonin in the intervertebral disc degeneration through inhibiting the ferroptosis of nucleus pulpous cells.
Not available
S-EPMC10424295 | biostudies-literature
UnknownmiRNA-141 Induced Pyroptosis in Intervertebral Disk Degeneration by Targeting ROS Generation and Activating TXNIP/NLRP3 Signaling in Nucleus Pulpous Cells.
Not available
S-EPMC7487322 | biostudies-literature
UnknownBioinformatics analysis reveals different gene expression patterns in the annulus fibrosis and nucleus pulpous during intervertebral disc degeneration.
Not available
S-EPMC6257805 | biostudies-literature
TranscriptomicsDynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc
N6-methyladenosine (m6A) modification, as one of the epigenetic modification of mRNAs, has been found implicating in various musculoskeletal disorders including IDD. However, the m6A dynamics in the progression of aging related IDD remain largely unknown. The purpose of this study was to investigate...
ORGANISM(S): Rattus norvegicus 
2023-06-15 | GSE234369 | GEO
TranscriptomicsNucleus pulposus related lncRNA and mRNA expression profiles in intervertebral disc degeneration
Intervertebral disc degeneration (IDD) leads to low back pain and disability globally. The pathophysiology of IDD is not entirely understood. There is increasing evidence that long noncoding RNAs (lncRNAs) play a key regulatory role in a wide range of biological processes. The purpose of this study ...
ORGANISM(S): Homo sapiens 
2023-02-09 | GSE186542 | GEO
GenomicsNucleus pulposus related lncRNA and mRNA expression profiles in intervertebral disc degeneration
Nucleus pulposus related lncRNA and mRNA expression profiles in intervertebral disc degeneration
PRJNA774342 | ENA
ProteomicsMatrisome remodelling during Intervertebral Disc development and ageing
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investi...
ORGANISM(S): Bos taurus (Bovine) 
2017-09-25 | PXD005616 | Pride
Foetus Extracellular matrix Development Intervertebral disc Ageing 
UnknownMatrisome Profiling During Intervertebral Disc Development And Ageing.
Not available
S-EPMC5599645 | biostudies-literature
UnknownKartogenin-enhanced dynamic hydrogel ameliorates intervertebral disc degeneration via restoration of local redox homeostasis.
Not available
S-EPMC10407629 | biostudies-literature
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