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ProteomicsOlfactory bulb proteomics in human Alzheimer's disease
Olfactory dysfunction is among the earliest features of Alzheimer´s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis was performed across different AD stages using a label-free...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD005319 | Pride
Proteomics Olfactory bulb 
ProteomicsAcetylome Analyses Provide New Insights into the Effects of Childhood Allergic Rhinitis on Olfactory Bulb-Dependent Olfactory Impairment
Background: Allergic rhinitis (AR) is a global health burden affecting 20% of the pediatric population and is characterized by nasal inflammation and frequent olfactory dysfunction. Protein acetylation, which is a frequently occurring posttranslational modification, plays pivotal roles in the regula...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD066708 | Pride
Allergic rhinitis  children  olfactory dysfunction  olfactory bulb  lysine acetylation 
TranscriptomicsGenome-wide expression analysis of E18.5 and P30 olfactory bulbs of control and Tshz1 mutant mice
Analysis of genes regulated by Tshz1 in olfactory bulb neurons. Total RNA from olfactory bulbs of embryonic day E18.5 and postnatal day 30 control mice was compared to Tshz1 mutant mice
ORGANISM(S): Mus musculus 
2023-10-12 | E-GEOD-51761 | biostudies-arrayexpress
ProteomicsOlfactory bulb proteome characterization in APP/PS1 mice
Here we used double-transgenic amyloid precursor protein/presenilin 1 (APPswe/PS1dE9) mice and label-free quantitative proteomics to analyze potential early pathological effects on the olfactory bulb (OB) during AD progression.
ORGANISM(S): Mus musculus (Mouse) 
2016-08-09 | PXD003683 | Pride
Olfactory bulb Proteomics 
ProteomicsTime-dependent olfactory proteomics in Tg2576 mice
Olfaction is often deregulated in Alzheimer´s disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegenerat...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-28 | PXD007813 | Pride
Olfactory bulb Proteomics Alzheimer 
ProteomicsOlfactory proteomics in amyotrophic lateral sclerosis
Despite smell impairment has been considered a potential non-motor finding in ALS, the pathobiochemistry at olfactory level remains unknown. Here, we applied an olfactory quantitative proteotyping approach to analyze the magnitude of the olfactory bulb (OB) proteostatic imbalance in ALS subjects (n=...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021630 | Pride
Olfactory bulb Proteomics Olfactory marker protein Amyotrophic lateral slcerosis 
TranscriptomicsTranscription profiling of mouse olfactory epithelium frpm Harlequin mutants compared to littermate controls
Microarray analysis of gene expression in the olfactory epithelium of Harlequin mouse as a model of oxidative-stress induced neurodegeneration of olfactory sensory neurons Experiment Overall Design: Olfactory epithelium from Harlequin mutant mice and littermate control mice was microdissected for RN...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6485 | biostudies-arrayexpress
ProteomicsOlfactory bulb proteomics of CMS-treated rats
We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the olfactory bulb were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrome...
ORGANISM(S): Rattus Norvegicus 
2021-04-12 | PXD023766 |
ProteomicsComparative gene and protein expression profile of olfactory ensheathing cells from olfactory bulb and olfactory mucosa
Olfactory ensheathing cells are one of the few central nervous system regenerative cells discovered so far. It is characterized by its lifelong nerve regeneration function, and it can also release a variety of neurotrophic factors and neural adhesion molecules. It is considered to be the glial cell ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024046 | Pride
Olfactory ensheathing cells (oecs)  olfactory bulb (ob)  olfactory mucosa (om)  gene  protein  gene ontology (go)  kyoto encyclopedia of genes and genomes (kegg)  molecular function  cellular component  biological process 
TranscriptomicsGene Expression Profiles of Adult Human Olfactory Bulb and Embryonic Neural Stem Cells
Global gene expression profiling was performed using RNA from human embryonic neural stem cells (hENSCs) and adult human olfactory bulb-derived neural stem cells (OBNSCs) to define a gene expression pattern and signaling pathways that are specific for each cell lineage. Subtractive gene expression p...
ORGANISM(S): Homo sapiens 
2012-01-30 | E-GEOD-35390 | biostudies-arrayexpress
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