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TranscriptomicsThe difference of gene expression in mouse OPCs in normothermic and hypothermic culture
We have found that the cell yield of oligodendrocyte precursor cells (OPCs) are higher in 31.5 degC than in 37 degC not by suppression of apoptosis but by enhancement of proliferation. Here, we performed transcriptome analysis using Affymetrix GeneChip on the primary cultured oligodendrocyte precurs...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-20645 | biostudies-arrayexpress
GenomicsActivation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination [ChIP-seq]
We investigate the role of Brg1 and Olig2 during oligodendrocyte differentiation by combining gene conditional knockout and next generation sequencing technology. We generate genome-wide maps of RNA polymerase II (RPolII), Brg1 (Smarca4), Olig2 and histone modifications in primary rat oligodendrocyt...
ORGANISM(S): Rattus norvegicus 
2013-01-20 | E-GEOD-42447 | biostudies-arrayexpress
ProteomicsDifferential serum proteomics of neuromyelitis spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are two types of autoimmune-mediated central nervous system (CNS) inflammatory demyelinating diseases that have similar clinical manifestations but with different pathogenesis a...
ORGANISM(S): Homo Sapiens 
2024-12-25 | PXD059225 |
ProteomicsChanges in the oligodendrocyte cell progenitor cell proteome with ageing
Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-25 | PXD010383 | Pride
Tandem mass tags Lc-ms Proteome Oligodendrocyte cell progenitor cell 
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
TranscriptomicsRapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
Stem cell biology has garnered much attention due to its potential to impact human health through disease modeling and cell replacement therapy. This is especially pertinent to myelin-related disorders such as multiple sclerosis and leukodystrophies where restoration of normal oligodendrocyte funct...
ORGANISM(S): Mus musculus 
2011-10-02 | E-GEOD-31562 | biostudies-arrayexpress
ProteomicsInvestigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics
Oligodendrocytes, the myelinating cells of the central nervous system, are essential for correct brain function. They originate from oligodendrocyte precursor cells (OPCs) through a differentiation process which is only incompletely understood and impaired in a variety of demyelinating diseases. Bet...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-21 | PXD012544 | Pride
Quantification Tmt labeling Oligodendrocytes Mass spectrometry Oligodendrocyte precursor cells 
TranscriptomicsCD133/CD140a-Based Isolation of Distinct Human Multipotent Neural Progenitor Cells and Oligodendrocyte Progenitor Cells
The mechanisms underlying the specification of oligodendrocyte fate from multipotent neural progenitor cells (NPCs) in developing human brain are unknown. In this study, we sought to identify antigens sufficient to distinguish NPCs free from oligodendrocyte progenitor cells (OPCs). We investigated t...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-40676 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in QKI knockdown CG-4 cells
QKI is required for myelin formation in the verterbrate brain. It functions by binding RNA and regulating its stability, translation, and/or aternative splicing. We have used Affymetrix exon arrays to assess changes in gene expression in response to QKI knockdown on an exon level in rat CG-4 oligod...
ORGANISM(S): Rattus norvegicus 
2011-01-20 | E-GEOD-26716 | biostudies-arrayexpress
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