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ProteomicsAn oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies
Oncogene addiction provides important therapeutic opportunities for precision oncology treatment strategies. To date the cellular circuitries associated with driving oncoproteins, which eventually establish the phenotypic manifestation of oncogene addiction remain largely unexplored. We employed a t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037406 | Pride
Oncogene addiction Phosphosignature Human Selected reaction monitoring 
TranscriptomicsGenomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: aCGH Arrays
Summary: Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smal...
ORGANISM(S): Homo sapiens 
2008-02-29 | E-GEOD-10025 | biostudies-arrayexpress
ProteomicsSystematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD052856 | Pride
Cell culture Ewing sarcoma 
TranscriptomicsGenomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: Expression Arrays
Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smallest regi...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9994 | biostudies-arrayexpress
GenomicsOncogene cooperation in human leukemia
Oncogene cooperation in human leukemia
PRJNA940078 | ENA
TranscriptomicsGenomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer
Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smallest regi...
ORGANISM(S): Homo sapiens 
2008-02-29 | E-GEOD-9995 | biostudies-arrayexpress
GenomicsOncogene regulated release of extracellular vesicles
Oncogene regulated release of extracellular vesicles
PRJNA541302 | ENA
GenomicsOncogene inactivation induced senescence facilitates tumor relapse
Oncogene inactivation induced senescence facilitates tumor relapse
PRJEB78692 | ENA
ProteomicsProteomic profiling of oncogene-induced HCC in mouse models
Oncogene activation drives changes in pathways related to cell proliferation, metabolism, and immune evasion, offering insights into molecular events underpinning hepatocarcinogenesis
ORGANISM(S): Mus musculus (Mouse) 
2026-04-16 | PXD064126 | Pride
Immune evasion Proteomics Hcc Oncogene 
UnknownAn mRNA expression-based signature for oncogene-induced replication-stress.
Not available
S-EPMC7612401 | biostudies-literature
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