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ProteomicsSARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are new identified symptoms of COVID‐19, and both of these are related to cilia dysfunction. However, the pathological me...
ORGANISM(S): Homo Sapiens 
2022-02-23 | PXD031842 |
Proteomicsd133 ORF10 immunoprecipitation from WT and TorsinKO cells
WT and TorsinKO HeLa cells were transfected with d133-ORF10-FLAG from KSHV. The protein was immunoprecipitated with anti-FLAG beads to investigate proteins contained within nuclear envelope blebs. A control sample with no specific immunoprecipitation was compared to the co-immunoprecipitations. Elut...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD036264 | Pride
Kshv Torsin Nuclear envelope Orf10 
GenomicsMonitoring ORF10's Impact on Host Transcriptome Using Doxycycline-Inducible A549 and 293T Cell Lines.
Monitoring ORF10's Impact on Host Transcriptome Using Doxycycline-Inducible A549 and 293T Cell Lines.
PRJNA1182805 | ENA
UnknownStructural insights into ORF10 recognition by ZYG11B.
Not available
S-EPMC9121654 | biostudies-literature
TranscriptomicsMonitoring ORF10's Impact on Host Transcriptome Using Doxycycline-Inducible A549 and 293T Cell Lines.
To monitor ORF10s effects on the host transcriptome, doxycycline-inducible cell lines were create in A549 and 293T(HEK) cells expressing ORF10. Because doxycycline itself can alter gene expression, we used doxycycline-inducible cell lines driving GFP as control. Empty vectors were used as well.
ORGANISM(S): Homo sapiens 
2024-12-04 | GSE281252 | GEO
UnknownSARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity.
Not available
S-EPMC9184850 | biostudies-literature
UnknownSARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease.
Not available
S-EPMC10705665 | biostudies-literature
UnknownMolecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10.
Not available
S-EPMC7604486 | biostudies-literature
UnknownORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Not available
S-EPMC8092598 | biostudies-literature
UnknownSARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites.
Not available
S-EPMC11413682 | biostudies-literature
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