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TranscriptomicsIdentification of DNA methylation changes in monocytes to osteoclast differentiation
Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system involving differentiation and massive cell fusion. Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in seve...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-46648 | biostudies-arrayexpress
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6082 | MetaboLights
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Targeted lipidomics assay without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6084 | MetaboLights
MetabolomicsUridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis

Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading 

to excessive bone resorption and microarchitectural deterioration. Although the interconnection 

between osteoclast differentiation and cellular energy metabolism has been inc...

2026-04-09 | MTBLS13394 | MetaboLights
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays after inhibition with FSG67 and Triacsin C)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6083 | MetaboLights
ProteomicsPhosphoproteomics of osteoclast differentiation in NT and CD300ld KO RAW264.7 cells
This dataset contains mass spectrometry–based phosphoproteomics of murine RAW264.7 macrophage cells comparing non-targeting control (NT) and CD300ld knockout (CD300ld KO) lines following in vitro osteoclast differentiation. Cells were induced toward osteoclasts using the standard RANKL-driven differ...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-20 | PXD073705 | Pride
Raw264.7 Tmt Osteoclast differentiation Cd300ld Phosphoproteomics Lc-ms/ms 
TranscriptomicsGene expression analysis of transcriptome changes regulated by RANKL-RANK signaling in macrophage cell line RAW 264.7
Bone remodeling relies on the precise developmental control of osteoclasts that resorb bone and osteoblasts that lay down fresh bone matrix. The hematopoietically derived osteoclast follow a tigthly controlled genetic program where specific genes are up-regulated to aid bone resorption.Some of them ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-21639 | biostudies-arrayexpress
OtherCharacterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling.
Data from ProteomeXchange, PXD ID: PXD000471. Experiment: 101207_EA_E, file: 101215_EA_E13.mzml. Published as part of . From the Abstract: {{i}} In addition to forming macrophages and dendritic cells, monocytes in adult peripheral blood retain the ability to develop into osteoclasts, mature bone-re...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM11210028860 | GPMDB
Resource Reanalysis 
TranscriptomicsmiR-155 role in osteoclast differentiation
We used microarrays to understand the effect miR-155 has on osteoclast differentiation. RAW264.7 cells were grown in a-MEM supplemented with 10% FBS and antibiotics. mRNA extracted from wild-type RAW264.7 cells and miR-155 mis-expressing cells either before or after 72 hr of stimulation with 20ng/ml...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-16749 | biostudies-arrayexpress
GenomicsTranscriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
PRJNA1034586 | ENA
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