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ProteomicsCholangiocarcinoma Cell of PDHA1 MS
The discovery of various lysine acylations raises a question as to whether they are subject to dynamic regulation and, if so, by which enzymes. Since acyltransferases play a crucial role in the succinylation process (acyltransferases are responsible for coupling acyl-CoA to non-protein substrates...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060056 | Pride
Pdha1 Ms Cholangiocarcinoma 
TranscriptomicsThe effect of FOXO3 knockdown and PDHA1 knockdown on PDAC cell line Panc-1
Little is known about the role of FOXO3 and PDHA1 in PDAC. We performed microarrays to revealed the transcriptional change of a human pancreatic ductal adenocarcinoma (PDCA) cell line (Panc -1) to scr-siRNA, FOXO3-siRNA and PDHA1-siRNA in order to provide insight into the role of PDHA1 and FOXO3 in...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-66404 | biostudies-arrayexpress
GenomicsPDHA1 Crotonylation Is Essential for Endometrial Metabolic Reprogramming and Decidualization in Normal Pregnancy
PDHA1 Crotonylation Is Essential for Endometrial Metabolic Reprogramming and Decidualization in Normal Pregnancy
PRJNA1452785 | ENA
TranscriptomicsPDHA1 Crotonylation Is Essential for Endometrial Metabolic Reprogramming and Decidualization in Normal Pregnancy
Endometrial decidualization is essential for pregnancy. Impaired decidualization is a hallmark of preeclampsia (PE), yet the underlying mechanisms remain unclear. Herewe show that uterine pyruvate dehydrogenase E1 subunit α (PDHA1) K385 crotonylation (K385cr) is crucial in metabolic reprogramming an...
ORGANISM(S): Homo sapiens 
2026-04-27 | GSE327790 | GEO
TranscriptomicsThe effect of FOXO3 knockdown and PDHA1 knockdown on PDAC cell line Panc-1
Little is known about the role of FOXO3 and PDHA1 in PDAC. We performed microarrays to revealed the transcriptional change of a human pancreatic ductal adenocarcinoma (PDCA) cell line (Panc -1) to scr-siRNA, FOXO3-siRNA and PDHA1-siRNA in order to provide insight into the role of PDHA1 and FOXO3 in ...
ORGANISM(S): Homo sapiens 
2016-09-01 | GSE66404 | GEO
UnknownRNF4 mediated degradation of PDHA1 promotes colorectal cancer metabolism and metastasis.
Not available
S-EPMC11550450 | biostudies-literature
UnknownSHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1.
Not available
S-EPMC10409927 | biostudies-literature
UnknownPLK1-mediated PDHA1 phosphorylation drives metabolic reprogramming in lung cancer.
Not available
S-EPMC12503065 | biostudies-literature
UnknownComprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.
Not available
S-EPMC9393251 | biostudies-literature
UnknownAstragaloside IV increases PDHA1 in mesenchymal stem cell exosomes to treat myocardial infarction.
Not available
S-EPMC12259979 | biostudies-literature
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