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ProteomicsAutoimmune peptide antigen reactivity in normal B6 mice Pepperchip 2.0
The aim of the array was to determine the B6 mouse sera IgG and IgM reactivity profile to linear peptide epitopes. Pooled sera from three 6-9 month old B6 mice was diluted at 1:200 for IgG specific analysis or 1:1000 for IgM specific analysis and incubated on a PEPperPRINT peptide microarray platfo...
ORGANISM(S): Mus musculus 
2015-02-28 | E-GEOD-65277 | biostudies-arrayexpress
ProteomicsAutoimmune peptide antigen reactivity in BXD2 mice with spontaneous systemic autoimmune disease
The aim of the study was to determine autoimmune BXD2 mouse sera reactivity to linear peptide epitopes from the Immune Epitope Database. Pooled sera from six 8-10 month old BXD2 mice was diluted at 1:1000 and incubated on a PEPperPRINT peptide microarray platform printed with peptide autoantigens. ...
ORGANISM(S): Mus musculus 
2015-02-28 | E-GEOD-65276 | biostudies-arrayexpress
ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080859 | MassIVE
ProteomicsAutoimmune peptide antigen reactivity in BXD2 mice with spontaneous systemic autoimmune disease Pepperchip 2.0
The aim of the array was to determine the BXD2 mouse sera IgG and IgM reactivity profile to linear peptide epitopes. Pooled sera from three 6-9 month old BXD2 mice was diluted at 1:200 for IgG specific analysis or 1:1000 for IgM specific analysis and incubated on a PEPperPRINT peptide microarray pl...
ORGANISM(S): Mus musculus 
2015-02-28 | E-GEOD-65278 | biostudies-arrayexpress
TranscriptomicsThe IDA-LIKE peptides IDL6 and IDL7 are negative modulators of stress responses in Arabidopsis thaliana
We present a functional characterisation of two members of the IDA-LIKE (IDL) peptide family in Arabidopsis thaliana, IDL6 and IDL7. They are processed both C- and N-terminally to produce active peptides. Structure analyses of synthesized IDL6 and IDL7 peptides indicate that they lack secondary stru...
ORGANISM(S): Arabidopsis thaliana 
2016-03-31 | E-GEOD-77467 | biostudies-arrayexpress
ProteomicsUnveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles both in the innate and adaptive immune system. Starting already during embryogenesis and continuing throughout our lives, these three Ags exert major functions in immune tolerance, defense against infections, and...
ORGANISM(S): Homo sapiens (Human) 
2018-04-20 | PXD009531 | Pride
Hla-e Hla-g Binding prediction  peptide motifs Hla-c Lc-msms 
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - peptide-protein interaction screen
Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of proteins. Since these mutations do not affect protein structure, the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a peptide-based proteomic screen to investigate the impact of mutati...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010027 | Pride
Peptide array Ppi Protein-protein interaction Disordered regions 
UnknownTriscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders.
Not available
S-EPMC11379947 | biostudies-literature
UnknownHelical structure motifs made searchable for functional peptide design.
Not available
S-EPMC8748493 | biostudies-literature
UnknownThe role of peptide motifs in the evolution of a protein network.
Not available
S-EPMC2095796 | biostudies-literature
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