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TranscriptomicsPro-tumorigenic effects of HLA-G in Renal Cell Carcinoma
Renal cell carcinoma (RCC) frequently exhibits high expression of the immunomodulatory molecule HLA-G, which promotes immune tolerance and tumor progression. To define the cell-intrinsic transcriptional programs driven specifically by HLA-G1 neo-expression, we generated RCC7/HLA-G1 cells by lentivir...
ORGANISM(S): Homo sapiens 
2026-05-01 | E-MTAB-16395 | biostudies-arrayexpress
TranscriptomicsTranscriptional characterization of primary human HLA-G+ extravillous trophoblasts (EVT) and Villous trophoblasts (VT)
Seven patient paired primary human HLA-G+ extravillous trophoblasts (EVT) and Villous trophoblasts (VT) obtained from 1st trimester (7-9 weeks) villous tissue were obtained. RNA was isolated directly after isolation and purification using FACS sort for CD45-HLA-G+ (EVT) and CD45-HLA-G-EGFR1+ (VT) fr...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-MTAB-3217 | biostudies-arrayexpress
ProteomicsUnveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles both in the innate and adaptive immune system. Starting already during embryogenesis and continuing throughout our lives, these three Ags exert major functions in immune tolerance, defense against infections, and...
ORGANISM(S): Homo sapiens (Human) 
2018-04-20 | PXD009531 | Pride
Hla-e Hla-g Binding prediction  peptide motifs Hla-c Lc-msms 
TranscriptomicsMicro array gene expression analysis of three types of HLA-G+ EVT
Three types of HLA-G+ EVT were purified from placental tissues. To investigate transcriptional differences RNA was isolated and gene expression profiles were generated by employing Affymetrix HG_U133_Plus 2 arrays on the Affymetrix Geneatlas system.
ORGANISM(S): Homo sapiens 
2020-06-16 | E-MTAB-8639 | biostudies-arrayexpress
TranscriptomicsComparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas
The goal of the present study was to characterize HLA-G-positive cells derived from human embryonic stem cells treated with BMP4 for five days and compare them to HLA-G positive cells derived from human first trimester placentas Human embryonic stem cells were cultured with BMP4 in the absence of F...
ORGANISM(S): Homo sapiens 
2013-05-02 | E-GEOD-42112 | biostudies-arrayexpress
TranscriptomicsBone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.
In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expres...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-25623 | biostudies-arrayexpress
GenomicsPro-tumorigenic effects of HLA-G in Renal Cell Carcinoma
Pro-tumorigenic effects of HLA-G in Renal Cell Carcinoma
PRJEB105427 | ENA
UnknownHuman leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer.
Not available
S-EPMC12583952 | biostudies-literature
ClinicalStudy of RO7515629 in Participants With HLA-G Positive Solid Tumors
The main purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, immune response and preliminary anti-tumor activity of RO7515629 alone in participants with advanced or metastatic solid tumors expressing human leukocyte antigen G (HLA-G).
11560 | ecrin-mdr-crc
UnknownHLA-G expression in peritumoral fundic gland mucous neck cells, but not in tumor lesions, related to poor survival in patients with gastric cancer.
Not available
S-EPMC12571866 | biostudies-literature
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