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ProteomicsThe MICOS-MIB complex member PERM1 connects mitochondria with the sarcolemma via ankyrin B
Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profili...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-16 | PXD025745 | Pride
Mitochondria  skeletal muscle  perm1  proteomics 
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-05-05 | PXD020395 | Pride
Heart development  phosphoproteomics  silac  mitochondria  perm1  lipid metabolism 
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-21 | MSV000085796 | MassIVE
TranscriptomicsPERM1 Gene Therapy Prevents Pressure Overload-induced Heart Failure Through a Sarcomere-Mitochondria Energetic Microdomain
Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractile function and mitochondrial dysfunction, yet therapies that simultaneously restore cardiac energetics and mechanical performance remain limited. Here, we demonstrate that adeno-associated virus (AAV)-mediate...
ORGANISM(S): Mus musculus 
2026-09-30 | GSE338319 | GEO
UnknownPERM1 regulates mitochondrial energetics through O-GlcNAcylation in the heart.
Not available
S-EPMC12646366 | biostudies-literature
UnknownPerm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training.
Not available
S-EPMC6480336 | biostudies-literature
UnknownPERM1 regulates energy metabolism in the heart via ERRα/PGC-1α axis.
Not available
S-EPMC9676655 | biostudies-literature
UnknownPerm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
Not available
S-EPMC7310723 | biostudies-literature
UnknownAnalysis of systolic cardiac function in PERM1-knockout mice using large cohorts of animals.
Not available
S-EPMC12946242 | biostudies-literature
UnknownPerm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.
Not available
S-EPMC4714556 | biostudies-literature
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